Invitrogen

CHD1L Polyclonal Antibody

CHD1L Antibody in Immunocytochemistry (ICC/IF)

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CHD1L Antibody (PA5-55940) in ICC/IF

Immunofluorecent analysis of CHD1L in human cell line U-2 OS using CHD1L Polyclonal Antibody (Product # PA5-55940). Staining shows localization to nucleoplasm.

CHD1L Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CHD1L Antibody in Immunohistochemistry (IHC)

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CHD1L Antibody — Relative expression in different tissues in IHC: Detection of differential expression levels of CHD1L demonstrates antibody specificity. Immunohistochemical analysis of CHD1L using anti-CHD1L Polyclonal Antibody (Product # PA5-55940), shows significant staining of CHD1L in human testis and shows minimal or weak staining in human pancreas tissues. The relative expression levels of CHD1L within each tissue is shown using RNA-Seq. {RE}

产品信息

PA5-55940

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.04-0.4 µg/mL

免疫组化（石蜡） (IHC (P))

1:500-1:1,000

免疫细胞化学 (ICC/IF)

0.25-2 µg/mL

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human CHD1L. Recombinant protein control fragment (Product #RP-94193).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.50 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2639756

产品详细信息

Immunogen sequence: GSRDQEEGKN HMYLFEGKDY SKEPSKEDRK SFEQLVNLQK TLLEKASQEG RSLRNKGSVL IPGLVEGSTK RKRVLSPEEL EDRQKKRQEA AAKRRRLIEE KKR

Highest antigen sequence identity to the following orthologs: Mouse - 76%, Rat - 78%.

靶标信息

In response to DNA strand breaks, chromatin adopts a relaxed structure due to the addition of poly(ADP-ribose) (PAR) to chromatin proteins by PARP enzymes (see PARP1; MIM 173870), and this relaxation facilitates the repair of DNA damage. CHD1L interacts with PAR and has a role in chromatin relaxation following DNA damage (Ahel et al., 2009 [PubMed 19661379]).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: amplified in liver cancer 1; Amplified in liver cancer protein 1; chromodomain helicase DNA binding protein 1-like; Chromodomain-helicase-DNA-binding protein 1-like

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基因别名: ALC1; CHD1L; CHDL

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UniProt ID: (Human) Q86WJ1

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Entrez Gene ID: (Human) 9557

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功能

nucleotide binding nucleic acid binding ATP-dependent DNA helicase activity protein binding ATP binding ATPase activity

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