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Product Details
PA5-63133
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CHD5. Recombinant protein control fragment (Product #RP-103713).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2639759
Product Specific Information
Immunogen sequence: GYMDEKDPGA QKPRQPLEVQ ALPAALDRVE SEDKHESPAS KERAREERPE ETEKAPPSPE QLPREEVLPE KEKILDKLEL SLIHSR
Highest antigen sequence identity to the following orthologs: Mouse - 67%, Rat - 67%.
Target Information
CHD5 (Chromodomain helicase DNA binding protein 5) is a member of the SNF2/RAD54 helicase family of chromatin remodeling and DNA-binding proteins (CDH proteins). Heavily expressed in both fetal and adult brain, CHD5 plays a role in nervous system development and acts as a tumor suppressor via the Arf/p53 pathway. CHD5, along with other chromo-domain proteins, forms remodeling complexes, such as NuRD, that promote normal neuroblast maturation and are thought to prevent overexpression of neuronal cells. Errors in these chromatin remodeling complexes can leave the cell in a perpetual state of growth, preventing differentiation and leading to tumor formation. Due to the importance of the CHD proteins in proper brain development, deletions in the gene encoding CHD5 are commonly found in neuroblastomas, suggesting that CHD5 deficiency may lead to malignant cell transformation and metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-dependent helicase CHD5; CHD-5; CHD5; Chromodomain-helicase-DNA-binding protein 5
Gene Aliases: CHD-5; CHD5; KIAA0444
UniProt ID: (Human) Q8TDI0
Entrez Gene ID: (Human) 26038
transcription, DNA-templated
negative regulation of cell proliferation
cerebral cortex neuron differentiation
spermatogenesis, exchange of chromosomal proteins
histone H4 acetylation
regulation of transcription involved in cell fate commitment
histone H3-K27 trimethylation
positive regulation of signal transduction by p53 class mediator
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