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CHM Antibody (PA5-95618) in ICC/IF
Immunocytochemistry analysis of CHM using anti-CHM antibody (Product # PA5-95618) . CHM was detected in an immunocytochemical section of SiHa cells. Enzyme antigen retrieval was performed using IHC enzyme antigen retrieval reagent for 15 mins. The cells were blocked with 10% goat serum and then incubated with 5 μg/mL rabbit anti-CHM antibody (Product # PA5-95618) overnight at 4°C. DyLight®488 Conjugated Goat Anti-Rabbit IgG was used as secondary antibody at 1:100 dilution and incubated for 30 minutes at 37°C. The section was counterstained... View More
产品信息
PA5-95618
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence of human CHM (QDQILENEEAIALSRKDKTIQHVEVFCYASQDLHED).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Affinity chromatography
保存液
PBS with 4mg trehalose
内含物
0.05mg sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2807420
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
靶标信息
Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: choroideraemia protein homolog; choroideremia (Rab escort protein 1); Choroideremia protein; Choroideremia protein homolog; choroidermia; Rab escort protein 1; Rab proteins geranylgeranyltransferase component A 1; REP-1; TCD protein
基因别名: CHM; DXS540; GGTA; HSD-32; REP-1; REP1; TCD
UniProt ID: (Human) P24386, (Rat) P37727
Entrez Gene ID: (Human) 1121, (Mouse) 12662, (Rat) 24942
