Osenses

CHMP4B, C Polyclonal Antibody

产品信息

OSC00061W-100UL

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:300-1:2,000

免疫组化 (IHC)

1:300-1:2,000

其他PubMed (Misc)

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产品规格

种属反应

Human, Mouse, Rat

已发表种属

Not Applicable

宿主/亚型

Rabbit / Ig

分类

Polyclonal

类型

Antibody

抗原

A synthetic peptide from the n-terminal of human CHMP4B, C conjugated to an immunogenic carrier protein was used as the antigen

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

Conc. Not Determined

保存液

whole serum

内含物

no preservative

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.

The peptide is homologous in many other species including rat, mouse, zebrafish and xenopus.

Specificity of this antibody: CHMP4B, C.

靶标信息

Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting.

The Journal of biological chemistry

Katoh K,Shibata H,Suzuki H,Nara A,Ishidoh K,Kominami E,Yoshimori T,Maki M

Fri Oct 03 00:00:00 UTC 2003

The DNA sequence and comparative analysis of human chromosome 20.

Nature

Deloukas P,Matthews LH,Ashurst J,Burton J,Gilbert JG,Jones M,Stavrides G,Almeida JP,Babbage AK,Bagguley CL,Bailey J,Barlow KF,Bates KN,Beard LM,Beare DM,Beasley OP,Bird CP,Blakey SE,Bridgeman AM,Brown AJ,Buck D,Burrill W,Butler AP,Carder C,Carter NP,Chapman JC,Clamp M,Clark G,Clark LN,Clark SY,Clee CM,Clegg S,Cobley VE,Collier RE,Connor R,Corby NR,Coulson A,Coville GJ,Deadman R,Dhami P,Dunn M,Ellington AG,Frankland JA,Fraser A,French L,Garner P,Grafham DV,Griffiths C,Griffiths MN,Gwilliam R,Hall RE,Hammond S,Harley JL,Heath PD,Ho S,Holden JL,Howden PJ,Huckle E,Hunt AR,Hunt SE,Jekosch K,Johnson CM,Johnson D,Kay MP,Kimberley AM,King A,Knights A,Laird GK,Lawlor S,Lehvaslaiho MH,Leversha M,Lloyd C,Lloyd DM,Lovell JD,Marsh VL,Martin SL,McConnachie LJ,McLay K,McMurray AA,Milne S,Mistry D,Moore MJ,Mullikin JC,Nickerson T,Oliver K,Parker A,Patel R,Pearce TA,Peck AI,Phillimore BJ,Prathalingam SR,Plumb RW,Ramsay H,Rice CM,Ross MT,Scott CE,Sehra HK,Shownkeen R,Sims S,Skuce CD,Smith ML,Soderlund C,Steward CA,Sulston JE,Swann M,Sycamore N,Taylor R,Tee L,Thomas DW,Thorpe A,Tracey A,Tromans AC,Vaudin M,Wall M,Wallis JM,Whitehead SL,Whittaker P,Willey DL,Williams L,Williams SA,Wilming L,Wray PW,Hubbard T,Durbin RM,Bentley DR,Beck S,Rogers J

Thu Jan 31 00:00:00 UTC 2002

生物信息学

蛋白别名: Charged multivesicular body protein 4b; Charged multivesicular body protein 4c; CHMP4b; CHMP4c; chromatin modifying protein 4B; chromatin modifying protein 4C; Chromatin-modifying protein 4b; Chromatin-modifying protein 4c; hSnf7-2; hSnf7-3; hVps32-2; hVps32-3; SNF7 homolog associated with Alix 1; SNF7 homolog associated with Alix 3; Snf7 homologue associated with Alix 1; Snf7 homologue associated with Alix 3; SNF7-2; SNF7-3; Vacuolar protein sorting-associated protein 32-2; Vacuolar protein sorting-associated protein 32-3; vacuolar protein-sorting-associated protein 32-2; Vps32-2; Vps32-3

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基因别名: 2010012F05Rik; 2010012P02Rik; 2210015K02Rik; 2310010I16Rik; C20orf178; C76846; CHMP4A; CHMP4B; CHMP4C; CTPP3; CTRCT31; dJ553F4.4; RGD1309846; RGD1565889; SHAX1; SHAX3; SNF7; SNF7-2; SNF7-3; Vps32-2; VPS32B; VPS32C