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产品信息
PA5-53124
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.19 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2639793
产品详细信息
Immunogen sequence: SETPGKGGGS SSSSERSQPG AEGSPETPPG RCCRCCRAPR LLQAYSWKEE EEEDEGSMES LTSSEGEEPG SEVVIKMPMV DPEAQAPTKQ PPRSSPNTVK RPTKKGRDRA GKGQKPRGKE QLAKRKTFSL VKE
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 97%.
靶标信息
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13.
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生物信息学
蛋白别名: acetylcholine receptor; acetylcholine receptor, muscarinic 1; cholinergic receptor; cholinergic receptor, muscarinic 1; M1 mAChR; MGC30125; Muscarinic acetylcholine receptor M1
基因别名: CHRM1; HM1; M1; M1R
UniProt ID: (Human) P11229
Entrez Gene ID: (Human) 1128
regulation of vascular smooth muscle contraction
cellular protein modification process
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
protein kinase C-activating G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
G-protein coupled acetylcholine receptor signaling pathway
synaptic transmission, cholinergic
neuromuscular synaptic transmission
nervous system development
cell proliferation
positive regulation of cell proliferation
regulation of locomotion
positive regulation of ion transport
saliva secretion
cognition
positive regulation of intracellular protein transport
