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产品信息
PA5-90876
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence within amino acids 251-350 of human CHRM1 (NP_0007292)
偶联物
形式
Liquid
浓度
0.96 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2806269
产品详细信息
Positive Samples: U-87MG, HepG2; Cellular Location: Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse
Immunogen sequence: SPETPPGRCC RCCRAPRLLQ AYSWKEEEEE DEGSMESLTS SEGEEPGSEV VIKMPMVDPE AQAPTKQPPR SSPNTVKRPT KKGRDRAGKG QKPRGKEQLA
靶标信息
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: acetylcholine receptor; acetylcholine receptor, muscarinic 1; AChR M1; cholinergic receptor; Cholinergic receptor, muscarin 1; cholinergic receptor, muscarinic 1; M1 mAChR; m1 muscarinic acetylcholine receptor protein; MGC30125; Muscarinic acetylcholine receptor M1
基因别名: Chrm-1; CHRM1; HM1; M1; M1R
UniProt ID: (Human) P11229, (Mouse) P12657, (Rat) P08482
Entrez Gene ID: (Human) 1128, (Mouse) 12669, (Rat) 25229
regulation of vascular smooth muscle contraction
cellular protein modification process
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
protein kinase C-activating G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
G-protein coupled acetylcholine receptor signaling pathway
synaptic transmission, cholinergic
neuromuscular synaptic transmission
nervous system development
cell proliferation
positive regulation of cell proliferation
regulation of locomotion
positive regulation of ion transport
saliva secretion
cognition
positive regulation of intracellular protein transport
sensory perception of chemical stimulus
regulation of ion transport
