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Product Details
PA5-33430
Product Specifications
Species Reactivity
Bovine,
Human,
Non-human primate,
Sheep,
Rabbit
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 20 amino acid peptide from 3rd cytoplasmic domain of human CHRM2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2550810
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Marmoset, Sheep, Bovine, Elephant, Panda, Rabbit, Platypus (100%).
Target Information
Muscarinic cholinergic receptor 2 (CHRM2) is an Acetylcholine Receptor has been suggested to function as a presynaptic autoreceptor that inhibits acetylcholine release. The M2 receptor has also been suggested to mediate smooth muscle contractility. Alzheimer's disease (AD) involves selective loss of M2 subtype receptors in cortical and hippocampal regions of the human brain. Increase in M2 receptor heterozygosity has been associated with depression in women. The M2 receptor has been reported to be expressed in various regions of the brain including the cerebellum, cerebral cortex, hippocampus, medulla, striatum, and thalamus, and in lung and prostate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 7TM receptor; acetylcholine receptor; acetylcholine receptor, muscarinic 2; cholinergic receptor; cholinergic receptor, muscarinic 2; cholinergic receptor, muscarinic 2, isoform a; FLJ43243; M2-mAChR; m2AChR; MGC120006; MGC120007; Muscarinic acetylcholine receptor M2; muscarinic M2 receptor
Gene Aliases: CHRM2; HM2
UniProt ID: (Bovine) P41985, (Human) P08172
Entrez Gene ID: (Rabbit) 100342878, (Bovine) 522170, (Human) 1129, (Sheep) 101102897
G-protein coupled acetylcholine receptor signaling pathway
regulation of heart contraction
response to virus
G protein-coupled serotonin receptor signaling pathway
regulation of synaptic vesicle exocytosis
regulation of smooth muscle contraction
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
synaptic transmission, cholinergic
nervous system development
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