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CHRM4 Antibody (PA5-115016) in ICC/IF
Immunocytochemistry analysis of CHRM4 in HeLa cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-115016) at a dilution of 1:200 (1 hr at 37°C). Secondary staining was applied with mouse anti-beta tubulin; AlexaFluor 594 conjugated goat anti-rabbit IgG (Red); AlexaFluor 88 conjugated goat anti-mouse IgG (Green) and DAPI (blue) using a dilution of 1:200 (1 hr at 37°C).
产品信息
PA5-115016
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human CHRM4(Accession P08173), corresponding to amino acid residues A243-S293.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2899652
产品详细信息
Antibody detects endogenous levels of total CHRM4.
靶标信息
Muscarinic acetylcholine receptor M4 is an Acetylcholine Receptor. Unlike muscarinic receptor M2, the M4 receptor is not involved in smooth muscle contraction. The clinical relevance of this receptor is unknown. However, mouse studies have linked it to adenylyl cyclase inhibition. Muscarinic acetylcholine receptor M4 has been reported to be expressed in many regions of the rat brain, particularly the striatum and hippocampus. ESTs have been isolated from human breast and eye libraries.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: acetylcholine receptor; acetylcholine receptor, muscarinic 4; AChR M4; cholinergic receptor; cholinergic receptor, muscarin 4; cholinergic receptor, muscarinic 4; Mm4 mAChR; muscarinic acetylcholine receptor 4; Muscarinic acetylcholine receptor M4
基因别名: Chrm-4; CHRM4; HM4; M4; M4R
UniProt ID: (Human) P08173, (Mouse) P32211, (Rat) P08485
Entrez Gene ID: (Human) 1132, (Mouse) 12672, (Rat) 25111
signal transduction
cell surface receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
G-protein coupled acetylcholine receptor signaling pathway
synaptic transmission, cholinergic
cell proliferation
regulation of locomotion
positive regulation of GTPase activity
G-protein coupled receptor signaling pathway
chemical synaptic transmission
sensory perception of chemical stimulus
response to organic substance
