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CHRNA4 Antibody (PA5-95773) in WB
Western blot analysis of CHRNA4 in mouse kidney. Samples were incubated with CHRNA4 Polyclonal antibody (Product # PA5-95773) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.
产品信息
PA5-95773
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 29-242 of human ACHA4 (P43681)
偶联物
形式
Liquid
浓度
0.91 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2807575
产品详细信息
Positive Samples: Mouse kidney; Cellular Location: Cell junction, Cell membrane, Lipid-anchor, Multi-pass membrane protein, postsynaptic cell membrane, synapse
Immunogen sequence: HVETRAHAEE RLLKKLFSGY NKWSRPVANI SDVVLVRFGL SIAQLIDVDE KNQMMTTNVW VKQEWHDYKL RWDPADYENV TSIRIPSELI WRPDIVLYNN ADGDFAVTHL TKAHLFHDGR VQWTPPAIYK SSCSIDVTFF PFDQQNCTMK FGSWTYDKAK IDLVNMHSRV DQLDFWESGE WVIVDAVGTY NTRKYECCAE IYPDITYAFV IRRL
靶标信息
This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: a4 nicotinic receptor; acetylcholine receptor; acetylcholine receptor alpha 4 neural; acetylcholine receptor, neuronal, nicotinic, alpha-4 subunit; alpha4 nAChR; alpha4-nAChR; cholinergic receptor; CHRNA 4; nAChR alpha 4; Neuronal acetylcholine receptor subunit alpha-4
基因别名: Acra-4; Acra4; Chrna4; EBN1; ENFL1
UniProt ID: (Mouse) O70174
Entrez Gene ID: (Mouse) 11438
action potential
response to hypoxia
DNA repair
transport
ion transport
cation transport
calcium ion transport
response to oxidative stress
signal transduction
synaptic transmission, cholinergic
respiratory gaseous exchange
locomotory behavior
regulation of dopamine secretion
sensory perception of pain
positive regulation of dopamine secretion
ion transmembrane transport
response to nicotine
behavioral response to nicotine
exploration behavior
B cell activation
regulation of membrane potential
neurological system process
cognition
protein heterooligomerization
membrane depolarization
inhibitory postsynaptic potential
cation transmembrane transport
regulation of acetylcholine-gated cation channel activity
