Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
图: 1 / 1
CHRNA4 Antibody (MA5-37815) in WB
Western blot analysis of CHRNA4 in extracts of various cell lines. Samples were incubated with CHRNA4 Monoclonal antibody (Product # MA5-37815) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.
产品信息
MA5-37815
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
ARC1822
抗原
A synthetic peptide corresponding to a sequence within amino acids 500-600 of human ACHA4 (P43681)
偶联物
形式
Liquid
浓度
0.6 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2897739
产品详细信息
Positive Samples: C6, SH-SY5Y, Mouse liver, U-251MG, Mouse brain, Rat testis
Immunogen sequence: PEADGQAAGA LASRNTHSAE LPPPDQPSPC KCTCKKEPSS VSPSATVKTR STKAPPPHLP LSPALTRAVE GVQYIADHLK AEDTDFSVKE DWKYVAMVID R
靶标信息
This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: a4 nicotinic receptor; acetylcholine receptor; acetylcholine receptor alpha 4 neural; acetylcholine receptor, neuronal, nicotinic, alpha-4 subunit; alpha4 nAChR; alpha4-nAChR; cholinergic receptor; cholinergic receptor, nicotinic alpha 4; cholinergic receptor, nicotinic, alpha 4 (neuronal); cholinergic receptor, nicotinic, alpha 4 subunit; cholinergic receptor, nicotinic, alpha polypeptide 4; CHRNA 4; nAChR alpha 4; Neuronal acetylcholine receptor subunit alpha-4; Neuronal nicotinic acetylcholine receptor alpha 4 subunit; neuronal nicotinic acetylcholine receptor alpha-4 subunit
基因别名: Acra-4; Acra4; BFNC; CHRNA4; EBN; EBN1; ENFL1; NACHR; NACHRA4; NACRA4; NARAC
UniProt ID: (Human) Q4JGR7, (Mouse) O70174, (Rat) P09483
Entrez Gene ID: (Human) 1137, (Mouse) 11438, (Rat) 25590
acetylcholine-activated cation-selective channel activity
ligand-gated ion channel activity
acetylcholine receptor activity
acetylcholine binding
ion channel activity
extracellular ligand-gated ion channel activity
protein binding
drug binding
protein heterodimerization activity
ligand-gated ion channel
action potential
response to hypoxia
DNA repair
ion transport
calcium ion transport
response to oxidative stress
signal transduction
chemical synaptic transmission
synaptic transmission, cholinergic
neuromuscular synaptic transmission
respiratory gaseous exchange
locomotory behavior
regulation of dopamine secretion
sensory perception of pain
response to nicotine
behavioral response to nicotine
exploration behavior
B cell activation
regulation of membrane potential
neurological system process
cognition
membrane depolarization
inhibitory postsynaptic potential
cation transmembrane transport
transport
cation transport
positive regulation of dopamine secretion
ion transmembrane transport
protein heterooligomerization
regulation of acetylcholine-gated cation channel activity
