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CLASP2 Antibody (PA5-109547) in WB
Western blot analysis of CLASP2 in extracts of various cell lines. Samples were incubated with CLASP2 Polyclonal antibody (Product # PA5-109547) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
产品信息
PA5-109547
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 220-400 of human CLASP2 (NP_001193973.1).
偶联物
形式
Liquid
浓度
1.04 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2854958
产品详细信息
Immunogen sequence: NCTSKSVPVR RRSFEFLDLL LQEWQTHSLE RHAAVLVETI KKGIHDADAE ARVEARKTYM GLRNHFPGEA ETLYNSLEPS YQKSLQTYLK SSGSVASLPQ SDRSSSSSQE SLNRPFSSKW STANPSTVAG RVSAGSSKAS SLPGSLQRSR SDIDVNAAAG AKAHHAAGQS VRSGRLGAGA L
靶标信息
CLASP2 is microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CLASP2alpha; CLASP2gamma; CLIP associating protein 2; CLIP-associating protein 2; CLIP-associating protein CLASP2; Cytoplasmic linker-associated protein 2; hOrbit2; multiple asters (Mast)-like homolog 2; Protein Orbit homolog 2
基因别名: 1500004F14Rik; 8030404L10Rik; C77448; CLASP2; CLASP2beta; KIAA0627; mKIAA0627
UniProt ID: (Human) O75122, (Mouse) Q8BRT1, (Rat) Q99JD4
Entrez Gene ID: (Human) 23122, (Mouse) 76499, (Rat) 114514
microtubule cytoskeleton organization
vesicle targeting
microtubule nucleation
negative regulation of microtubule depolymerization
Golgi organization
mitotic spindle organization
sister chromatid cohesion
establishment or maintenance of cell polarity
exit from mitosis
regulation of gastrulation
positive regulation of epithelial cell migration
regulation of epithelial to mesenchymal transition
microtubule organizing center organization
regulation of microtubule polymerization or depolymerization
regulation of microtubule-based process
microtubule anchoring
positive regulation of exocytosis
cell division
negative regulation of stress fiber assembly
negative regulation of focal adhesion assembly
establishment of protein localization to plasma membrane
positive regulation of extracellular matrix disassembly
negative regulation of wound healing, spreading of epidermal cells
positive regulation of basement membrane assembly involved in embryonic body morphogenesis
cell cycle
mitotic nuclear division
cell migration
meiotic cell cycle
