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产品信息
ACL-001-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
GST fusion protein with the sequence SLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRPR, corresponding to amino acid residues 592-661 of rat CLC-3, Intracellular, near the C-terminus
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA, 5% sucrose
内含物
0.025% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).
靶标信息
Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: chloride channel 3; Chloride channel protein 3; chloride channel, voltage-sensitive 3; Chloride transporter ClC-3; CIC3; ClC-3; CLCN 3; DKFZp564I0463; H(+)/Cl(-) exchange transporter 3; protein kinase C-regulated chloride channel
基因别名: ClC-3; CLC3; CLCN3
UniProt ID: (Human) P51790, (Rat) P51792, (Mouse) P51791
Entrez Gene ID: (Human) 1182, (Rat) 84360, (Mouse) 12725
voltage-gated chloride channel activity
chloride channel activity
protein binding
ATP binding
antiporter activity
PDZ domain binding
chloride ion binding
protein homodimerization activity
protein heterodimerization activity
volume-sensitive chloride channel activity
ion channel activity
voltage-gated ion channel activity
nucleotide binding
ion channel
transport
regulation of pH
negative regulation of cell volume
endosomal lumen acidification
chloride transmembrane transport
regulation of anion transmembrane transport
ion transport
chloride transport
phagocytosis, engulfment
adult locomotory behavior
ion transmembrane transport
regulation of ion transmembrane transport
synaptic transmission, glutamatergic
regulation of anion transport
photoreceptor cell maintenance
synaptic transmission, GABAergic
neuron cellular homeostasis
synaptic vesicle lumen acidification
positive regulation of reactive oxygen species biosynthetic process
transmembrane transport
