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CLIP1 Antibody (PA5-142491) in WB
Western Blot analysis of CLIP1 in Human Breast Cancer lysate (35 µg protein in RIPA buffer) using CLIP1 Polyclonal Antibody, Biotin (Product # PA5-142491) at 1 µg/mL incubated for 1 hour. Detected by chemiluminescence, using streptavidin-HRP and using NAP blocker as a substitute for skimmed milk.
产品信息
PA5-142491
产品规格
种属反应
Human
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide with sequence C-PHSTHHGSRGEERP.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2933138
产品详细信息
Additional Information: This antibody is expected to recognize both reported isoforms (NP_002947.1; NP_937883.1).
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:8,000.
靶标信息
CLIP170 was initially identified as a new type of intermediate filament associated protein that is highly expressed in Reed-Sternberg cells, the tumoral cells diagnostic for Hodgkin's disease. Later experiments showed that it is located at microtubule plus ends and is required for the binding of endocytic carrier vesicles. CLIP170 has also been suggested to act with LIS1, a protein implicated in brain development, to regulate dynein/dynactin binding microtubules. Other studies suggest that CLIP170 can influence the formation of lamellipodia and cell invasion by invasive breast cancer cells by regulating the release of kinesin and IQGAP1 from a complex of those proteins, CLIP170 and Rac1. At least two isoforms of CLIP170 are known to exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CAP-Gly domain-containing linker protein 1; CLIP-170; Cytoplasmic linker protein 1; Cytoplasmic linker protein 170 alpha-2; cytoplasmic linker protein CLIP-170; MGC131604; Reed-Sternberg intermediate filament-associated protein; Restin; restin (Reed-Steinberg cell-expressed intermediate filament-associated protein)
基因别名: CLIP; CLIP-170; CLIP1; CLIP170; CYLN1; RSN
UniProt ID: (Human) P30622
Entrez Gene ID: (Human) 6249
