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CLIP1 Antibody (MA5-53324) in ICC/IF
Immunocytochemistry analysis of CLIP1 in HepG2 cells. Nuclei were stained blue with DAPI; CLIP1 recombinant monoclonal antibody (Product # MA5-53324) with a dilution of 1:1,000 was stained magenta with Alexa Fluor 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar: 20 μm.
产品信息
MA5-53324
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
23GB3080
抗原
A synthesized peptide derived from CLIP170 (1400-1438AA).
偶联物
形式
Liquid
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
靶标信息
CLIP170 was initially identified as a new type of intermediate filament associated protein that is highly expressed in Reed-Sternberg cells, the tumoral cells diagnostic for Hodgkin's disease. Later experiments showed that it is located at microtubule plus ends and is required for the binding of endocytic carrier vesicles. CLIP170 has also been suggested to act with LIS1, a protein implicated in brain development, to regulate dynein/dynactin binding microtubules. Other studies suggest that CLIP170 can influence the formation of lamellipodia and cell invasion by invasive breast cancer cells by regulating the release of kinesin and IQGAP1 from a complex of those proteins, CLIP170 and Rac1. At least two isoforms of CLIP170 are known to exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CAP-Gly domain-containing linker protein 1; Clip 170; CLIP-170; Cytoplasmic linker protein 1; Cytoplasmic linker protein 170; Cytoplasmic linker protein 170 alpha-2; cytoplasmic linker protein 50; cytoplasmic linker protein CLIP-170; MGC131604; Reed-Steinberg cell-espressed intermediate filament-associated protein; Reed-Sternberg intermediate filament-associated protein; Restin; restin (Reed-Steinberg cell-expressed intermediate filament-associated protein)
基因别名: 1110007I12Rik; 4631429H07Rik; AV017631; C81039; CLIP; CLIP-170; CLIP1; CLIP170; Clip50; CYLN1; Kiaa4046; mKIAA4046; restin; RSN
UniProt ID: (Human) P30622, (Mouse) Q922J3
Entrez Gene ID: (Human) 6249, (Mouse) 56430
