Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
图: 1 / 2
CNGA4 Antibody (APC-074-200UL) in IHC
Expression of CNGA4 in mouse olfactory bulb - Immunohistochemical staining of CNGA4 channel in mouse olfactory bulb using Anti-CNGA4 Antibody (#APC-074). A. CNGA4 staining (green) appears in glomeruli (horizontal arrows) and outside the glomeruli (vertical arrows). To define the location of glomeruli (G), the same section was stained with mouse Anti-synaptophysin (red) and the nissl stain DAPI (blue). B. Pre-incubation of Anti-CNGA4 Antibody with the peptide antigen blocks the staining in the olfactory bulb.
产品信息
APC-074-200UL
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C) SQDGKVKTTESTPPAPTK, corresponding to amino acid residues 2-19 of rat CNGA4, Intracellular, N-terminus
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Second messenger, cAMP, causes the opening of cation- selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: CNCalpha4, CNG5; cng channel; CNG channel alpha-4; CNG-4; CNG4; cyclic nucleotide gated cation channel; cyclic nucleotide-gated cation channel alpha 4; cyclic nucleotide-gated cation channel alpha-4; Cyclic nucleotide-gated channel alpha-4; cyclic nucleotide-gated olfactory channel subunit OCNC2; OCNC2; olfactory cyclic nucleotide-gated channel; Olfactory cyclic nucleotide-gated channel subunit 2
基因别名: Cgn2; Cnga4; rOCNC2
UniProt ID: (Mouse) Q3UW12, (Rat) Q64359
Entrez Gene ID: (Mouse) 233649, (Rat) 85258
nucleotide binding
ion channel activity
intracellular cyclic nucleotide activated cation channel activity
intracellular cAMP activated cation channel activity
intracellular cGMP activated cation channel activity
voltage-gated potassium channel activity
cAMP binding
cGMP binding
ligand-gated ion channel
transport
ion transport
sensory perception of smell
ion transmembrane transport
regulation of ion transmembrane transport
regulation of membrane potential
response to stimulus
protein heterotetramerization
transmembrane transport
potassium ion transmembrane transport
cation transmembrane transport
phototransduction, visible light
