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Immunogen sequence: LLAELESSAL KIAYRIERLE WQTREWPMPE DLAEADDEGE PEEGTSKDEE GRAS
Antigen sequence identity: Mouse 83%; Rat 87%
Second messenger, cAMP, causes the opening of cation- selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: cng channel; CNG channel alpha-4; cyclic nucleotide gated channel beta 2; Cyclic nucleotide-gated channel alpha-4; OCNC2; Olfactory cyclic nucleotide-gated channel subunit 2
基因别名: CNCA2; CNG-4; CNG4; CNG5; CNGA4; CNGB2; OCNC2; OCNCb; OCNCBETA
UniProt ID: (Human) Q8IV77
Entrez Gene ID: (Human) 1262