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CNGB1 Antibody (PA5-112936) in ICC/IF
Immunocytochemichal analysis of CNGB1 in A549 cells using a Polyclonal antibody (Product # PA5-112936) at a dilution of 1:66. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated Goat Anti-Rabbit IgG(H+L). Cells were also counter-stained with DAPI.
产品信息
PA5-112936
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Human Cyclic nucleotide-gated cation channel beta-1 protein (131-253AA)
偶联物
形式
Liquid
浓度
4.61 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.03% ProClin 300
保存条件
-20°C or -80°C if preferred
运输条件
Wet ice
RRID
AB_2867670
靶标信息
Glutamic acid rich protein (GARP) is a soluble protein localized to the outer segments of the rod photoreceptor. GARPs are characterized by six repeated motifs of: V V E K K N/E E. These repeat motifs help form an alpha-helix structure. The function(s) of GARP have not been fully characterized, but studies have suggested that GARP helps limit cGMP turnover by inhibiting phosphodiesterase activity. To date, there have been two splice variants characterized: GARP1 (full-length GARP) and GARP2 (truncated GARP). GARP also interacts with part of the larger cytoplasmic domain of the beta-subunit of the cyclic GMP-gated channel found in the plasma membrane.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cng channel; CNG channel 4; CNG channel beta-1; CNG-4; Cyclic nucleotide-gated cation channel 4; Cyclic nucleotide-gated cation channel gamma; Cyclic nucleotide-gated cation channel modulatory subunit; Cyclic nucleotide-gated channel beta-1; GARP; Glutamic acid-rich protein; glutamic-acid-rich protein
基因别名: CNCG2; CNCG3L; CNCG4; CNG4; CNGB1; CNGB1B; GAR1; GARP; GARP2; RCNC2; RCNCb; RCNCbeta; RP45
UniProt ID: (Human) Q14028
Entrez Gene ID: (Human) 1258
retina homeostasis
transport
cation transport
visual perception
sensory perception of smell
rhodopsin mediated signaling pathway
regulation of rhodopsin mediated signaling pathway
protein localization to organelle
photoreceptor cell outer segment organization
regulation of membrane potential
photoreceptor cell maintenance
detection of light stimulus involved in visual perception
potassium ion transmembrane transport
