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CNOT6 Antibody (PA5-81156) in WB
Western Blot using CNOT6 Polyclonal Antibody (Product # PA5-81156) at 1:500 dilution. Lane A: Jurkat Whole Cell Lysate. Lysates/proteins at 30 μg per lane. Secondary Goat Anti- RabbitIgG H&L (DyLight™ 800) at 1:10,000 dilution. Developed using the Odyssey technique. Performed under reducing conditions. Predicted band size: 63 kDa. Observed band size: 72 kDa.
产品信息
PA5-81156
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to the N-terminus of the Human CNOT6
偶联物
形式
Liquid
纯化类型
Protein A, Antigen affinity chromatography
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2788393
产品详细信息
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
This antibody has specificity for Human CNOT6.
靶标信息
Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Mediates cell proliferation and cell survival and prevents cellular senescence.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: carbon catabolite repression 4 protein; carbon catabolite repressor protein 4 homolog; CCR4-NOT transcription complex, subunit 6; cytoplasmic deadenylase
基因别名: CCR4; Ccr4a
Entrez Gene ID: (Human) 57472
nuclear-transcribed mRNA poly(A) tail shortening
transcription, DNA-templated
regulation of transcription, DNA-templated
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
positive regulation of cell proliferation
positive regulation of cytoplasmic mRNA processing body assembly
gene silencing by miRNA
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
nuclear-transcribed mRNA catabolic process, no-go decay
RNA phosphodiester bond hydrolysis, exonucleolytic
positive regulation of ligand-dependent nuclear receptor transcription coactivator activity
