Invitrogen

CNR2 Polyclonal Antibody

CNR2 Antibody in Immunocytochemistry (ICC/IF)

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CNR2 Antibody (PA1-746A) in ICC/IF

Immunolocalization of CB2 in AtT20 cells transfected with the rat CB2 gene using Product # PA1-746A.

CNR2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CNR2 Antibody in Immunohistochemistry (IHC)

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产品信息

PA1-746A

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:50-1:500

查看3篇已发表文章 3篇已发表文章

免疫组化 (IHC)

查看6篇已发表文章 6篇已发表文章

免疫组化（石蜡） (IHC (P))

1:10-1:100

查看1篇已发表文章 1篇已发表文章

免疫组化（冰冻） (IHC (F))

查看1篇已发表文章 1篇已发表文章

免疫细胞化学 (ICC/IF)

1:500

流式细胞分析 (Flow)

Assay-dependent

产品规格

种属反应

Human, Rat

已发表种属

Hamster, Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

GST fusion protein containing the first 32 amino acid residues from Rat CB2.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS with 50% glycerol, 1mg/mL BSA

内含物

0.05% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

AB_2082908

产品详细信息

PA1-746A detects cannabinoid receptor 2 (CB2) from human and rat tissues as well as transfected rat CB2.

PA1-746A has been successfully used in WB, immunocytochemistry, immunohistochemistry (paraffin) and FACS procedures. Immunocytochemical staining of CB2 into AtT20 cells transfected with the rat CB2 gene with PA1-746 yields a pattern consistent with plasma membrane staining.

靶标信息

Cannabinoids exert their well known physiological effects through two G protein coupled receptors, cannabinoid receptor 1 (CB1) and CB2. Both cannabinoid receptors have been shown to inhibit adenylyl cyclase as well as stimulate the mitogen-activated protein kinase, MAPK. CB1 receptors also modulate ion channels through direct G-protein interactions. Delta 9-tetrahydrocannibinol and related ligands likely exert their psychoactive effects by inhibiting presynaptic N- and P/Q type calcium channels. CB2 is thought to function primarily in the immune system although it has been suggested to be present in the central nervous system, including the retina.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Spinal cannabinoid receptor 2 activation alleviates neuropathic pain by regulating microglia and suppressing P2X7 receptor.

Frontiers in molecular neuroscience

Zhou Y,Xu Y,Yang J,Yu Z,Wang W,Yuan M,Wang Y,Bai Q,Li Z

PA1-746A was used in Western Blotting to provide new insights into the neuroprotective mechanism of CB2R activation.

Tue Mar 28 00:00:00 UTC 2023

Synthetic Cannabinoid Agonist WIN 55212-2 Targets Proliferation, Angiogenesis, and Apoptosis via MAPK/AKT Signaling in Human Endometriotic Cell Lines and a Murine Model of Endometriosis.

Frontiers in reproductive health

Lingegowda H,Miller JE,Marks RM,Symons LK,Alward T,Lomax AE,Koti M,Tayade C

Published figure using CNR2 polyclonal antibody (Product # PA1-746A) in Immunohistochemistry

Sat Oct 29 00:00:00 UTC 2022

Microarray analysis of transcripts with elevated expressions in the rat medial or lateral habenula suggest fast GABAergic excitation in the medial habenula and habenular involvement in the regulation of feeding and energy balance.

Brain structure & function

Wagner F,Bernard R,Derst C,French L,Veh RW

PA1746A was used in immunohistochemistry to determine if medial or lateral habenula or their subnuclei display field-characteristic gene products

Thu Dec 01 00:00:00 UTC 2016

Neuronal expression of CB2 cannabinoid receptor mRNAs in the mouse hippocampus.

Neuroscience

Li Y,Kim J

PA1-746A was used in Western Blotting to study the mechanisms of CB2 cannabinoid receptor functions in the brain.

Thu Dec 17 00:00:00 UTC 2015

Islet cannabinoid receptors: cellular distribution and biological function.

Pancreas

Flores LE,Alzugaray ME,Cubilla MA,Raschia MA,Del Zotto HH,Román CL,Suburo AM,Gagliardino JJ

PA1-746A was used in immunohistochemistry to study the expression of cannabinoid receptors in rat islets and their physiological significance

Tue Oct 01 00:00:00 UTC 2013

Prevention of paclitaxel-induced neuropathy through activation of the central cannabinoid type 2 receptor system.

Anesthesia and analgesia

Naguib M,Xu JJ,Diaz P,Brown DL,Cogdell D,Bie B,Hu J,Craig S,Hittelman WN

PA1-746A was used in Immunohistochemistry on frozen tissues to examine the potential of cannabinoid type 2 agonists in preventing paclitaxel-induced neuropathy.

Tue May 01 00:00:00 UTC 2012

Overexpression of cannabinoid CB2 receptor in the brain induces hyperglycaemia and a lean phenotype in adult mice.

Journal of neuroendocrinology

Romero-Zerbo SY,Garcia-Gutierrez MS,Suárez J,Rivera P,Ruz-Maldonado I,Vida M,Rodriguez de Fonseca F,Manzanares J,Bermúdez-Silva FJ

PA1-746A was used in immunohistochemistry to study the effects of CB2 receptor overexpression in murine brain on body mass and glucose metabolism

Wed Aug 01 00:00:00 UTC 2012

Overexpression of cannabinoid CB2 receptor in the brain induces hyperglycaemia and a lean phenotype in adult mice.

Journal of neuroendocrinology

Romero-Zerbo SY,Garcia-Gutierrez MS,Suárez J,Rivera P,Ruz-Maldonado I,Vida M,Rodriguez de Fonseca F,Manzanares J,Bermúdez-Silva FJ

PA1-746A was used in immunohistochemistry to study the effects of CB2 receptor overexpression in murine brain on body mass and glucose metabolism

Wed Aug 01 00:00:00 UTC 2012

Involvement of the endocannabinoid system in periodontal healing.

Biochemical and biophysical research communications

Kozono S,Matsuyama T,Biwasa KK,Kawahara K,Nakajima Y,Yoshimoto T,Yonamine Y,Kadomatsu H,Tancharoen S,Hashiguchi T,Noguchi K,Maruyama I

PA1-746A was used in immunohistochemistry to study the role of endocannabinoid receptors in periodontal healing

Fri Apr 16 00:00:00 UTC 2010

Cannabinoid receptors in conjunctival epithelium: identification and functional properties.

Investigative ophthalmology & visual science

Iribarne M,Torbidoni V,Julián K,Prestifilippo JP,Sinha D,Rettori V,Berra A,Suburo AM

PA1-746A was used in Immunohistochemistry to explore the presence and properties of cannabinoid receptors in conjunctival epithelial cells.

Wed Oct 01 00:00:00 UTC 2008

Dual effect of anandamide on rat placenta nitric oxide synthesis.

Placenta

Cella M,Leguizamón GF,Sordelli MS,Cervini M,Guadagnoli T,Ribeiro ML,Franchi AM,Farina MG

PA1-746A was used in western blot to study the effect of anandamide on nitric oxide synthesis in rat placenta

Fri Aug 01 00:00:00 UTC 2008

生物信息学

蛋白别名: Cannabinoid Receptor 2; cannabinoid receptor 2 (macrophage); CB-2; CB2 receptor; CB2R; CNR3; CX5; HCB2; HGNC:2160; OTTHUMP00000044841; peripheral cannabinoid receptor; rCB2; RP11-4M23.1; testis-dominant CNR2 isoform CB2

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基因别名: CB-2; CB2; CB2A; CB2B; CB2C; CNR2; CNR2C; CX5

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UniProt ID: (Human) P34972, (Rat) Q9QZN9

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Entrez Gene ID: (Human) 1269, (Rat) 57302

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功能

cannabinoid receptor activity G-protein coupled receptor activity G-protein coupled receptor

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