Invitrogen

CNTFR Polyclonal Antibody

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CNTFR Antibody (PA5-45053) in WB

Western blot analysis of A549, H441 cells using an anti-CNTFR polyclonal antibody (Product # PA5-45053).

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产品信息

PA5-45053

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.2-1 µg/mL

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产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide directed towards the C-terminal of human CNTFR (aa 295-344).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS with 2% sucrose

内含物

0.09% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

AB_2609088

产品详细信息

Peptide sequence: VAAHATPWTE EPRHLTTEAQ AAETTTSTTS SLAPPPTTKI CDPGELGSGG

Sequence homology: Cow: 93%; Dog: 93%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 93%; Sheep: 93%

靶标信息

This gene encodes a hematopoeitin/interferon-class receptor belonging to the cytokine superfamily of receptors. The encoded gene product represents the CNTF-specific alpha subunit of a heterotrimer forming the CNTF receptor complex, which also includes LIFR and gp130. The receptor is attached to the membrane by a glycosyl-phosphatidylinositol linkage and contains an immunoglobulin-like C2-type domain and a fibronectin type-III domain. Signal transduction requires that CNTF bind first to this alpha component, which permits the recruitment of gp130 and LIFR beta to form the tripartite receptor complex. Signal transduction stimulates gene expression, cell survival or differentiation in a variety of neuronal cell types. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Ciliary Neurotrophic Factor Modulates Multiple Downstream Signaling Pathways in Prostate Cancer Inhibiting Cell Invasiveness.

Cancers

Tossetta G,Fantone S,Gesuita R,Goteri G,Senzacqua M,Marcheggiani F,Tiano L,Marzioni D,Mazzucchelli R

PA5-45053 was used in Western Blotting to show that CNTF is expressed in PCa and CRPC tissues, and has a pivotal role in prostate cancer environment remodeling and as a negative modulator of invasion processes of CRPC cell models.

Wed Nov 30 00:00:00 UTC 2022

Biological Effects of Ciliary Neurotrophic Factor on hMADS Adipocytes.

Frontiers in endocrinology

Perugini J,Di Mercurio E,Tossetta G,Severi I,Monaco F,Reguzzoni M,Tomasetti M,Dani C,Cinti S,Giordano A

PA5-45053 was used in Western Blotting to study the increased metabolism and decreased storage of lipids in human adipocytes due to ciliary neurotrophic factor.