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CNTFR Antibody (PA5-47757) in Neu
Neutralization of CNTFR in TF‚1 human erythroleukemic cell line. Samples were incubated in CNTFR polyclonal antibody (Product # PA5-47757). Recombinant Rat CNTF Rα enhances Recombinant Rat CNTF induced proliferation in the TF‚1 human erythroleukemic cell line in a dose-dependent manner (orange line). Enhancement of Recombinant Rat CNTF (10 ng/mL) activity elicited by Recombinant Rat CNTF Rα (0.25 µg/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Rat CNTF Rα Antigen Affinity-purified Polyclonal Antibody. The ND50 ... View More
产品信息
PA5-47757
产品规格
种属反应
Rat
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Sf 21-derived recombinant rat CNTF R alpha Ala19-Pro346
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2608048
产品详细信息
In direct ELISAs, approximately 50% cross-reactivity with recombinant human CNTF sR alpha is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
靶标信息
This gene encodes a hematopoeitin/interferon-class receptor belonging to the cytokine superfamily of receptors. The encoded gene product represents the CNTF-specific alpha subunit of a heterotrimer forming the CNTF receptor complex, which also includes LIFR and gp130. The receptor is attached to the membrane by a glycosyl-phosphatidylinositol linkage and contains an immunoglobulin-like C2-type domain and a fibronectin type-III domain. Signal transduction requires that CNTF bind first to this alpha component, which permits the recruitment of gp130 and LIFR beta to form the tripartite receptor complex. Signal transduction stimulates gene expression, cell survival or differentiation in a variety of neuronal cell types. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ciliary neurotrophic factor receptor alpha; Ciliary neurotrophic factor receptor subunit alpha; CNTF receptor subunit alpha; CNTFR alpha; CNTFR-alpha; MGC1774
基因别名: Cntfr
UniProt ID: (Rat) Q08406
Entrez Gene ID: (Rat) 313173
