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产品信息
PA5-36227
产品规格
种属反应
Human,
Mouse
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to amino acids 571-620 of human COL11A1
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2553426
产品详细信息
This antibody detects endogenous protein at a molecular weight of 181 kDa.
Purity is >95% by SDS-PAGE.
靶标信息
Collagen Type XI is an 1806 amino acid protein belonging to the fibrillar collagen family. Collagen Type XI is thought to play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils. This protein forms trimers composed of three different chains: a 1(XI), a 2(XI), and a 3(XI). a 3(XI) is a post-translational modification of a 1(II). a 1(V) can also be found instead of a 3(XI). Collagen Type XI has three named isoforms (A,B,C) and additional isoforms seem to exist, stemming from alternative usage of exon IIA or exon IIB. Transcripts containing exon IIA or IIB are present in cartilage, but exon IIB is preferentially utilized in transcripts from tendon. Collagen Type XI contains a single collagen binding TSP N-terminal (TSPN) domain. Collagen Type XI is expressed in cartilage, placenta and some tumor or virally transformed cell lines. Isoform expression can be tissue specific. Defects in the COL11A gene are the cause of Stickler syndrome type 2 (STL2), or beaded vitreous type, due to the presence of irregularly thickened fiber bundles throughout vitreous cavity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: a1(XI) collagen; chondrodysplasia; COBA1; Collagen alpha 1; Collagen alpha-1(XI) chain; collagen XI, alpha-1 polypeptide; collagen, type XI, alpha 1; pro-alpha1(XI) collagen; procollagen, type XI, alpha 1; STL3; XI chain precursor
基因别名: C530001D20Rik; cho; CO11A1; COL11A1; COLL6; STL2
UniProt ID: (Human) P12107, (Mouse) Q61245
Entrez Gene ID: (Human) 1301, (Mouse) 12814
cartilage condensation
ossification
chondrocyte development
proteoglycan metabolic process
visual perception
sensory perception of sound
extracellular matrix organization
collagen fibril organization
collagen catabolic process
endodermal cell differentiation
tendon development
inner ear morphogenesis
embryonic skeletal system morphogenesis
detection of mechanical stimulus involved in sensory perception of sound
ventricular cardiac muscle tissue morphogenesis
heart morphogenesis
skeletal system morphogenesis
cartilage development
