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COL4A3 Antibody (PA5-37854) in IHC (P)
Immunohistochemical analysis of COL4A3 in paraffin embedded human kidney using a COL4A3 polyclonal antibody (Product #PA5-37854) at a concentration of 4 µg/mL. Steamed antigen retrieval was performed with pH 6 buffered citrate. Samples were then stained with horseradish peroxidase.
产品信息
PA5-37854
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide with sequence C-RGPTEYYDTYQEK, from the internal region of COL4A3 (aa341-353)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2554462
产品详细信息
This antibody is predicted to react with dog and cow based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.
靶标信息
Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. [provided by RefSeq, Jun 2010].
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: collagen alpha-3; Collagen alpha-3(IV) chain; collagen IV, alpha-3 polypeptide; collagen, type IV, alpha 3 (Goodpasture antigen); Goodpasture antigen; IV chain; tumstatin
基因别名: COL4A3
UniProt ID: (Human) Q01955
Entrez Gene ID: (Human) 1285
activation of cysteine-type endopeptidase activity involved in apoptotic process
cell adhesion
cell surface receptor signaling pathway
sensory perception of sound
blood circulation
cell proliferation
negative regulation of cell proliferation
negative regulation of endopeptidase activity
negative regulation of angiogenesis
extracellular matrix organization
collagen catabolic process
glomerular basement membrane development
endothelial cell apoptotic process
