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COLQ Antibody (PA5-109572) in WB
Western blot analysis of COLQ in extracts of various cell lines. Samples were incubated with COLQ Polyclonal antibody (Product # PA5-109572) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 15s.
产品信息
PA5-109572
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 276-455 of human COLQ (NP_005668.2).
偶联物
形式
Liquid
浓度
0.7 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2854983
产品详细信息
Immunogen sequence: MGPKGERGFP GPPGRCLCGP TMNVNNPSYG ESVYGPSSPR VPVIFVVNNQ EELERLNTQN AIAFRRDQRS LYFKDSLGWL PIQLTPFYPV DYTADQHGTC GDGLLQPGEE CDDGNSDVGD DCIRCHRAYC GDGHRHEGVE DCDGSDFGYL TCETYLPGSY GDLQCTQYCY IDSTPCRYFT
靶标信息
COLQ (collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase), also known as EAD, is a 455 amino acid protein that localizes to the end plate of skeletal muscle. COLQ anchors the catalytic subunits of asymmetric AChE (acetylcholinesterase) to the basal lamina at the neuromuscular junctions of vertebrates. Mutations of COLQ lead to congenital myasthenic syndromes which are rare autosomal recessive diseases characterized by general weakness increased by exertion, ophthalmoplegia and refractoriness to anticholinesterase drugs. Eight isoforms exist due to alternative splicing events.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Acetylcholinesterase collagenic tail peptide; Acetylcholinesterase-associated collagen; AChE Q subunit; collagen-like tail subunit of asymmetric acetylcholinesterase
基因别名: A130034K24Rik; Colq
UniProt ID: (Mouse) O35348, (Rat) O35167
Entrez Gene ID: (Mouse) 382864, (Rat) 29755
