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COPS8 Antibody (MA5-52544) in ICC/IF
Immunocytochemistry analysis of COPS8 in HepG2 cells. Nuclei were stained blue with DAPI; COPS8 recombinant monoclonal antibody (Product # MA5-52544) with a dilution of 1:1,000 was stained magenta with Alexa Fluor 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: High. Scale bar: 20 μm.
产品信息
MA5-52544
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
23GB3100
抗原
A synthesized peptide derived from CSN8 (180-209AA).
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
靶标信息
COPS8 is a COP9 signalosome (CSN), which is an evolutionarily conserved protein complex of the eight subunits that interacts with deubiquitinating enzymes and protein kinases and is highly homologous to the lid sub-complex of 26S proteasome. The CSN complex is an essential regulator of the ubiquitin conjugation pathway by mediating the deneddylation of the SCF-type E3 ligase complexes, which leads to a decrease in ubiquitin ligase activity of SCF-complexes such as SCF, CSA or DDB2. It is also involved in phosphorylation of p53, c-jun/JUN, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN8 encodes the smallest and the least conserved but first identified subunit of CSN. Recent studies show CSN8 is essential for Drosophila development and is essential for peripheral T cell homeostasis and antigen receptor-induced entry into the cell cycle from quiescence.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: COP9 (constitutive photomorphogenic) homolog, subunit 8; COP9 constitutive photomorphogenic homolog subunit 8; COP9 homolog; COP9 signalosome complex subunit 8; COP9 signalosome subunit 8; hCOP9; JAB1-containing signalosome subunit 8; SGN8; signalosome subunit 8
基因别名: 9430009J09Rik; AA408242; COP9; COPS8; CSN8; SGN8
UniProt ID: (Human) Q99627, (Mouse) Q8VBV7, (Rat) Q6P4Z9
Entrez Gene ID: (Human) 10920, (Mouse) 108679, (Rat) 363283
