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Product Details
PA5-121106
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 50-369 of human COQ3 (NP_059117.3).
Conjugate
Form
Liquid
Concentration
0.74 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2914678
Product Specific Information
Positive test controls include: HeLa, NCI-H460, MCF7, Mouse liver, Mouse brain, Mouse heart, Mouse kidney, Rat liver. The target is usually found in the following locations: Matrix side, Mitochondrion inner membrane, Peripheral membrane protein.
Immunogen sequence: PGVFNEYRTI WFKSYRTIFS CLNRIKSFRY PWARLYSTSQ TTVDSGEVKT FLALAHKWWD EQGVYAPLHS MNDLRVPFIR DNLLKTIPNH QPGKPLLGMK ILDVGCGGGL LTEPLGRLGA SVIGIDPVDE NIKTAQCHKS FDPVLDKRIE YRVCSLEEIV EETAETFDAV VASEVVEHVI DLETFLQCCC QVLKPGGSLF ITTINKTQLS YALGIVFSEQ IASIVPKGTH TWEKFVSPET LESILESNGL SVQTVVGMLY NPFSGYWHWS ENTSLNYAAY AVKSRVQEHP ASAEFVLKGE TEELQANACT NPAVHEKLKK
Target Information
Ubiquinone, also known as coenzyme Q, or Q, is a critical component of the electron transport pathways of both eukaryotes and prokaryotes. This lipid consists of a hydrophobic isoprenoid tail and a quinone head group. The tail varies in length depending on the organism, but its purpose is to anchor coenzyme Q to the membrane. The quinone head group is responsible for the activity of coenzyme Q in the respiratory chain. The S. cerevisiae COQ3 gene encodes an O-methyltransferase required for 2 steps in the biosynthetic pathway of coenzyme Q. This enzyme methylates an early coenzyme Q intermediate, 3,4-dihydroxy-5-polyprenylbenzoic acid, as well as the final intermediate in the pathway, converting demethyl-ubiquinone to coenzyme Q. The COQ3 gene product is also capable of methylating the distinct prokaryotic early intermediate 2-hydroxy-6-polyprenyl phenol.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2-polyprenyl-6-hydroxyphenol methylase; 2-polyprenyl-6-hydroxyphenyl methylase; 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase; 3-demethylubiquinol 3-O-methyltransferase; 3-demethylubiquinone-10 3-methyltransferase; 3-demethylubiquinone-9 3-methyltransferase; Coenzyme Q (ubiquinone); coenzyme Q3 homolog methyltransferase; coenzyme Q3 homolog, methyltransferase; coenzyme Q3 methyltransferase; DHHB methyltransferase; DHHB-MT; DHHB-MTase; dihydroxyhexaprenylbenzoate methyltransferase; hexaprenyldihydroxybenzoate methyltransferase, mitochondrial; methyltransferase COQ3; Polyprenyldihydroxybenzoate methyltransferase; Ubiquinone biosynthesis O-methyltransferase, mitochondrial
Gene Aliases: 4732433J24; bA9819.1; C77934; COQ3; DHHBMT; DHHBMTASE; UG0215E05
UniProt ID: (Human) Q9NZJ6, (Mouse) Q8BMS4, (Rat) Q63159
Entrez Gene ID: (Human) 51805, (Mouse) 230027, (Rat) 29309
hexaprenyldihydroxybenzoate methyltransferase activity
O-methyltransferase activity
2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
3-demethylubiquinone-9 3-O-methyltransferase activity
S-adenosylmethionine-dependent methyltransferase activity
decaprenyldihydroxybenzoate methyltransferase activity
3-demethylubiquinone-10 3-O-methyltransferase activity
methyltransferase activity
transferase activity
methyltransferase
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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