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CPEB4 Antibody (PA5-115046) in ICC/IF
Immunocytochemistry analysis of CPEB4 in HeLa cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-115046). Secondary staining was applied with mouse anti-beta tubulin (1 hr at 37°, AlexaFluor 594 conjugated goat anti-rabbit IgG (Red), AlexaFluor 488 conjugated goat anti-mouse IgG (Green) and DAPI.
产品信息
PA5-115046
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human CPEB4(Accession Q17RY0), corresponding to amino acid residues A420-Y470.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2899682
产品详细信息
Antibody detects endogenous levels of total CPEB4.
靶标信息
Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR (PubMed:24990967). RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited. Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation (PubMed:26398195). Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT (PubMed:22138752). Stimulates proliferation of melanocytes (PubMed:27857118). In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CPE-binding protein 4; CPE-BP4; Cytoplasmic polyadenylation element-binding protein 4
基因别名: CPE-BP4; Cpeb-4; CPEB4; hCPEB-4; KIAA1673; mCPEB-4
UniProt ID: (Human) Q17RY0, (Mouse) Q7TN98
Entrez Gene ID: (Human) 80315, (Mouse) 67579, (Rat) 303010
response to ischemia
translation
ionotropic glutamate receptor signaling pathway
cellular response to decreased oxygen levels
cellular response to glucose starvation
negative regulation of neuron apoptotic process
cellular response to amino acid stimulus
negative regulation of cytoplasmic translation
