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CPSF4 Antibody (PA5-106349) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded CPSF4 in human gastric tissue. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with CPSF4 polyclonal antibody (Product # PA5-106349) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
产品信息
PA5-106349
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human CPSF4(Accession O95639), corresponding to amino acid residues L206-N256.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2854025
产品详细信息
Antibody detects endogenous levels of total CPSF4.
靶标信息
Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cleavage and polyadenylation specific factor 4, 30kD subunit; cleavage and polyadenylation specific factor 4, 30kDa; Cleavage and polyadenylation specificity factor 30 kDa subunit; Cleavage and polyadenylation specificity factor subunit 4; Clipper homolog; Clipper/CPSF 30K; CPSF 30 kDa subunit; musculus clipper/cleavage and polyadenylation specificity factor 30 kDa subunit; Neb-1; no; No arches homolog; no arches-like zinc finger protein; NS1 effector domain-binding protein 1
基因别名: 30kDa; C79664; CPSF30; CPSF4; NAR; NEB-1; NEB1
UniProt ID: (Human) O95639, (Mouse) Q8BQZ5
Entrez Gene ID: (Human) 10898, (Mouse) 54188
