Invitrogen

CPT1A Polyclonal Antibody

CPT1A Antibody in Immunohistochemistry (IHC)

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CPT1A Antibody (PA5-69347) in IHC

Immunohistochemistry was performed on human pancreatic cells tissue using a CPT1A polyclonal primary antibody (Product # PA5-69347) with a dilution of 1:300, anti-rabbit Alexa Fluor 488 with a secondary antibody dilution of 1:200 and CPT1A (green), and DAPI (blue).

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产品信息

PA5-69347

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.2-1.0 µg/mL

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免疫组化 (IHC)

1:200

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产品规格

种属反应

Human

已发表种属

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

synthetic peptide directed towards the middle region of human CPT1A

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Affinity chromatography

保存液

PBS with 2% sucrose

内含物

0.09% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

AB_2688596

产品详细信息

This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%; Zebrafish: 100%

靶标信息

The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Fatty acid β-oxidation promotes breast cancer stemness and metastasis via the miRNA-328-3p-CPT1A pathway.

Cancer gene therapy

Zeng F,Yao M,Wang Y,Zheng W,Liu S,Hou Z,Cheng X,Sun S,Li T,Zhao H,Luo Y,Li J

PA5-69347 was used in Immunohistochemistry to show that yield insights into the host homeostatic control of immune response and benefit the development of cancer immunotherapies.

Tue Mar 01 00:00:00 UTC 2022

Fatty acid β-oxidation promotes breast cancer stemness and metastasis via the miRNA-328-3p-CPT1A pathway.

Cancer gene therapy

Zeng F,Yao M,Wang Y,Zheng W,Liu S,Hou Z,Cheng X,Sun S,Li T,Zhao H,Luo Y,Li J

PA5-69347 was used in Immunohistochemistry to show that yield insights into the host homeostatic control of immune response and benefit the development of cancer immunotherapies.

Tue Mar 01 00:00:00 UTC 2022

Fatty acid β-oxidation promotes breast cancer stemness and metastasis via the miRNA-328-3p-CPT1A pathway.

Cancer gene therapy

Zeng F,Yao M,Wang Y,Zheng W,Liu S,Hou Z,Cheng X,Sun S,Li T,Zhao H,Luo Y,Li J

PA5-69347 was used in Immunohistochemistry to show that yield insights into the host homeostatic control of immune response and benefit the development of cancer immunotherapies.

Tue Mar 01 00:00:00 UTC 2022

Vitamin D modulates hepatic microRNAs and mitigates tamoxifen-induced steatohepatitis in female rats.

Fundamental & clinical pharmacology

Abd El-Haleim EA,Sallam NA

PA5-69347 was used in Western Blot to show that combination therapy of VD and TAM has complementary benefits in terms of safety and not only efficacy and should be further investigated clinically.

Fri Apr 01 00:00:00 UTC 2022

Downregulating carnitine palmitoyl transferase 1 affects disease progression in the SOD1 G93A mouse model of ALS.

Communications biology

Trabjerg MS,Andersen DC,Huntjens P,Oklinski KE,Bolther L,Hald JL,Baisgaard AE,Mørk K,Warming N,Kullab UB,Kroese LJ,Pritchard CEJ,Huijbers IJ,Nieland JDV

PA5-69347 was used in Immunohistochemistry to reveal that metabolism, and specifically CPT1 lipid metabolism plays a central role in the SOD1 G93A mouse model and shows that CPT1 might be a therapeutic target in ALS.

Fri Apr 30 00:00:00 UTC 2021

Downregulating carnitine palmitoyl transferase 1 affects disease progression in the SOD1 G93A mouse model of ALS.

Communications biology

Trabjerg MS,Andersen DC,Huntjens P,Oklinski KE,Bolther L,Hald JL,Baisgaard AE,Mørk K,Warming N,Kullab UB,Kroese LJ,Pritchard CEJ,Huijbers IJ,Nieland JDV

Fri Apr 30 00:00:00 UTC 2021

生物信息学

蛋白别名: Carnitine O-palmitoyltransferase 1, liver isoform; Carnitine O-palmitoyltransferase I, liver isoform; Carnitine palmitoyltransferase 1A; carnitine palmitoyltransferase 1A (liver); carnitine palmitoyltransferase I, liver; CPT 1; CPT I; CPT1 L; CPT1-L; CPTI-L; Succinyltransferase CPT1A

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基因别名: CPT1; CPT1-L; CPT1A; L-CPT1

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UniProt ID: (Human) P50416

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Entrez Gene ID: (Human) 1374

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功能

carnitine O-palmitoyltransferase activity identical protein binding palmitoleoyltransferase activity acyltransferase

参与通路