Invitrogen

CRABP2 Polyclonal Antibody

CRABP2 Antibody in Immunocytochemistry (ICC/IF)

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CRABP2 Antibody (PA5-27451) in ICC/IF

CRABP2 Polyclonal Antibody detects CRABP2 protein at cytoplasm and nucleus by immunofluorescent analysis. Sample: HCT116 cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: CRABP2 protein stained by CRABP2 Polyclonal Antibody (Product # PA5-27451) diluted at 1:500. Blue: Hoechst 33342 staining.

CRABP2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CRABP2 Antibody in Immunocytochemistry, Immunohistochemistry (Paraffin) (ICC/IF, IHC (P))

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产品信息

PA5-27451

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:3,000

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免疫组化（石蜡） (IHC (P))

1:100-1:1,000

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免疫细胞化学 (ICC/IF)

1:100-1:1,000

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产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fragment corresponding to a region within amino acids 1 and 138 of Human CRABP2

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7, with 1% BSA, 20% glycerol

内含物

0.01% thimerosal

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2544927

产品详细信息

Recommended positive controls: A549, HepG2, mouse brain, mouse fetal brain, rat brain.

Predicted reactivity: Mouse (94%), Rat (94%), Xenopus laevis (89%), Pig (95%), Rhesus Monkey (100%), Bovine (97%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

Cellular retinoic acid binding protein (CRABP) is a low molecular weight protein with unknown function and existing in two isoforms, CRABP1 and CRABP2. The predicted amino acid sequences of human CRABP1 and CRABP2 exhibits 99.3 and 93.5% identity to mouse CRABP1 and CRABP2, respectively. The CRABP2 isoform is important in retinoic acid-mediated regulation of human skin growth and differentiation. The CRABP2 gene localized on human chromosome 1q21.3 is transcriptionally regulated by a newly synthesized regulatory protein. The protein is expressed in human adult liver.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue.

Journal of the American Chemical Society

Chen W,Dong J,Plate L,Mortenson DE,Brighty GJ,Li S,Liu Y,Galmozzi A,Lee PS,Hulce JJ,Cravatt BF,Saez E,Powers ET,Wilson IA,Sharpless KB,Kelly JW

PA527451 was used in western blot to study the reactivity of arylfluorosulfates using the proteome of human cells as a substrate

Wed Jun 15 00:00:00 UTC 2016

Integrative proteomic profiling of ovarian cancer cell lines reveals precursor cell associated proteins and functional status.

Nature communications

Coscia F,Watters KM,Curtis M,Eckert MA,Chiang CY,Tyanova S,Montag A,Lastra RR,Lengyel E,Mann M

PA5-27451 was used in immunohistochemistry - paraffin section and western blot determine the origin of human high-grade serous ovarian cancer cells

Fri Aug 26 00:00:00 UTC 2016

Integrative proteomic profiling of ovarian cancer cell lines reveals precursor cell associated proteins and functional status.

Nature communications

Coscia F,Watters KM,Curtis M,Eckert MA,Chiang CY,Tyanova S,Montag A,Lastra RR,Lengyel E,Mann M

PA5-27451 was used in immunohistochemistry - paraffin section and western blot determine the origin of human high-grade serous ovarian cancer cells

Fri Aug 26 00:00:00 UTC 2016

生物信息学

蛋白别名: cellular lipid-binding protein; cellular retinoic acid binding protein II; Cellular retinoic acid-binding protein 2; Cellular retinoic acid-binding protein II; CRABP-II; RP11-66D17.4

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基因别名: AI893628; Crabp-2; CRABP-II; CRABP2; CrabpII; RBP6

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UniProt ID: (Human) P29373, (Mouse) P22935, (Rat) P51673

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Entrez Gene ID: (Human) 1382, (Mouse) 12904, (Rat) 29563

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功能

retinoic acid binding transporter activity retinoid binding protein binding retinal binding retinol binding lipid binding cyclin binding

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