Invitrogen

CRB2 Polyclonal Antibody

CRB2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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CRB2 Antibody (PA5-25628) in IHC (P)

Immunohistochemistry analysis of CRB2 in formalin fixed and paraffin embedded mouse kidney tissue. Samples were incubated with CRB2 polyclonal antibody (Product # PA5-25628) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of this antibody for immunohistochemistry. Clinical relevance has not been evaluated.

CRB2 Antibody in Immunocytochemistry (ICC/IF)

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产品信息

PA5-25628

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

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免疫组化（石蜡） (IHC (P))

1:50-1:100

免疫细胞化学 (ICC/IF)

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产品规格

种属反应

Human, Mouse

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KLH conjugated synthetic peptide between 1258-1285 amino acids of human CRUM2

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Protein A, Antigen affinity chromatography

保存液

PBS, pH 7.4

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_2543128

靶标信息

CRB2 (Crumbs homolog 2), like its homologs CRB1 and CRB3, is similar to the Drosophila crumbs protein and is expressed in retina, brain and kidney. Along with other proteins, the Crumbs proteins form a complex that help set up cell polarity in developing neuroepithelial cells. At the onset of neural specification, embryonic stem cells (ESCs) upregulate CRB2, which then localizes apically in neural rosettes. Gain- and loss-of-function studies of CRB2 have shown that CRB2 is essential for the stabilization of other polarity proteins. Unlike CRB1, mutations in CRB2 do not appear to play a role in retinitis pigmentosa or in Leber congenital amaurosis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Downregulation of iNOS/NO Promotes Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer.

Molecular cancer research : MCR

Du Q,Liu S,Dong K,Cui X,Luo J,Geller DA

Published figure using CRB2 polyclonal antibody (Product # PA5-25628) in Western Blot

Wed Feb 01 00:00:00 UTC 2023

Vitamin B3, nicotinamide, enhances mitochondrial metabolism to promote differentiation of the retinal pigment epithelium.

The Journal of biological chemistry

Hazim RA,Paniagua AE,Tang L,Yang K,Kim KKO,Stiles L,Divakaruni AS,Williams DS

PA5-25628 was used in Immunocytochemistry to investigate the ways in which mitochondrial metabolism affect retinal pigment epithelium cellular functions are not clear.

Thu Sep 01 00:00:00 UTC 2022

Vitamin B3, nicotinamide, enhances mitochondrial metabolism to promote differentiation of the retinal pigment epithelium.

The Journal of biological chemistry

Hazim RA,Paniagua AE,Tang L,Yang K,Kim KKO,Stiles L,Divakaruni AS,Williams DS

PA5-25628 was used in Immunocytochemistry to investigate the ways in which mitochondrial metabolism affect retinal pigment epithelium cellular functions are not clear.