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产品信息
PA5-113738
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide directed towards the C-terminal region of Human CRH (aa 142-191).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2884253
产品详细信息
Immunogen sequence: GGHQEAPERE RRSEEPPISL DLTFHLLREV LEMARAEQLA QQAHSNRKLM
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Predicted homology: Cow: 85%; Dog: 100%; Guinea Pig: 93%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Sheep: 92%; Zebrafish: 93%
靶标信息
Corticotropin Releasing Factor (CRF), a 41 amino acids neuropeptide, belongs to a family of structurally related peptides including urocortin, sauvagine and urotensin I. CRF is critical in the regulation of the pituitary-adrenal gland axis, and in endocrine, autonomic and behavioral responses to stress. CRF is widely distributed in the brain and peripheral nervous system with the highest levels in the hypothalamic paraventricular nucleus.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Corticoliberin; Corticotropin-releasing factor; Corticotropin-releasing hormone; CRF
基因别名: CRF; CRH; CRH1
UniProt ID: (Human) P06850
Entrez Gene ID: (Human) 1392
positive regulation of protein phosphorylation
synaptic transmission, dopaminergic
glucocorticoid biosynthetic process
inflammatory response
signal transduction
chemical synaptic transmission
female pregnancy
parturition
learning or memory
positive regulation of cell proliferation
associative learning
hormone-mediated apoptotic signaling pathway
positive regulation of gene expression
negative regulation of gene expression
negative regulation of norepinephrine secretion
positive regulation of circadian sleep/wake cycle, wakefulness
positive regulation of cell death
regulation of serotonin secretion
diterpenoid metabolic process
hypothalamus development
lung development
adrenal gland development
positive regulation of cAMP biosynthetic process
negative regulation of epinephrine secretion
negative regulation of luteinizing hormone secretion
locomotory exploration behavior
positive regulation of insulin secretion involved in cellular response to glucose stimulus
response to immobilization stress
negative regulation of circadian sleep/wake cycle, REM sleep
response to drug
response to estrogen
response to ethanol
response to ether
negative regulation of blood pressure
response to pain
ion homeostasis
response to corticosterone
positive regulation of corticotropin secretion
positive regulation of cortisol secretion
long-term synaptic potentiation
positive regulation of digestive system process
negative regulation of cell death
negative regulation of glucagon secretion
cellular response to cocaine
cellular response to dexamethasone stimulus
positive regulation of calcium ion import
regulation of N-methyl-D-aspartate selective glutamate receptor activity
positive regulation of corticosterone secretion
positive regulation of behavioral fear response
