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CRHR2 Antibody (720291) in ICC/IF
Immunofluorescence was performed on HEK-293 cells transfected with CRHR2 expression plasmid. 24 hours post transection, cells were fixed and permeabilized for detection of CRHR2 using Anti-Corticotropin releasing hormone receptor 2 Rabbit Polyclonal Antibody (Product # 720291, 2 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection and localization of CRHR2 protein (green), Panel b... View More
产品信息
720291
产品规格
种属反应
Human,
Mouse
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide corresponding to Human CRHR2 (aa 24-38)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.2, with 0.1% BSA, 30% glycerol
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2633243
产品详细信息
These Polyclonal antibodies are of rabbit origin developed by immunizing animals with proteins or peptides. The polyclonal antibody is purified by affinity purification from the rabbit sera generated after immunizing the rabbits with a specific type of protein or peptide. The purified antibody is tested for its functionality in various relevant research applications. The antibody is developed for Research Use Only and is non-hazardous or non-infectious in nature.
This antibody is predicted to react with Monkey, Pig, Rat and Mouse.
靶标信息
Corticotropin-releasing hormone (CRH; 122560) is a 41-amino acid peptide synthesized in the hypothalamus, and play a role in the neuroregulation, responses to stress and immune challenge. Corticotropin Releasing Factor Receptor 2 (CRHR2) was the receptor of CRH. The sepression of CRHR2 has been reported in various regions of the brain as well as in placenta, umbilical vein, heart, epididymis, gastrointestinal tract, adrenal and skeletal muscle.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: corticotropin releasing factor receptor type 2 beta; corticotropin-releasing factor 2; Corticotropin-releasing factor receptor 2; Corticotropin-releasing hormone receptor 2; CRF 2 receptor; CRF-R-2; CRF-RB; CRF2 receptor, beta isoform; CRFR-2; CRH receptor 2 variant B; CRH-R-2; CRH-R2; Crh2 receptor
基因别名: CRF-R2; CRF-RB; CRF2; CRF2R; CRFR2; CRFR2alpha; CRFR2beta; CRH2R; CRHR2; HM-CRF
UniProt ID: (Human) Q13324, (Mouse) Q60748
Entrez Gene ID: (Human) 1395, (Mouse) 12922
actin filament organization
cell surface receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
protein kinase C-activating G-protein coupled receptor signaling pathway
hormone-mediated signaling pathway
positive regulation of heart rate
positive regulation of gene expression
negative regulation of gene expression
negative regulation of norepinephrine secretion
positive regulation of serotonin secretion
sensory perception of pain
cerebellum development
hypothalamus development
negative regulation of cAMP biosynthetic process
positive regulation of cAMP biosynthetic process
epithelial cell differentiation
positive regulation of interleukin-6 production
negative regulation of epinephrine secretion
positive regulation of stress-activated MAPK cascade
negative regulation of luteinizing hormone secretion
gastric motility
catecholamine biosynthetic process
positive regulation of blood pressure
negative regulation of follicle-stimulating hormone secretion
skeletal muscle tissue growth
positive regulation of NF-kappaB transcription factor activity
long-term synaptic potentiation
negative regulation of insulin secretion involved in cellular response to glucose stimulus
regulation of ERK1 and ERK2 cascade
cellular response to corticotropin-releasing hormone stimulus
cellular response to glucocorticoid stimulus
negative regulation of calcium ion import
negative regulation of feeding behavior
negative regulation of defecation
signal transduction
G-protein coupled receptor signaling pathway
negative regulation of angiogenesis
positive regulation of cAMP metabolic process
positive regulation of cAMP-mediated signaling
negative regulation of cAMP-mediated signaling
