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产品信息
PA5-50643
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to a region derived from internal residues of human cysteine rich transmembrane BMP regulator 1 (chordin-like)
偶联物
形式
Liquid
浓度
1.5 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 40% glycerol
内含物
0.05% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2636096
产品详细信息
The antibody detects endogenous levels of total CRIM1 protein.
靶标信息
CRIM1 (cysteine-rich motor neuron 1), a glycosylated type I transmembrane protein, plays a role in tissue development i.e. capillary formation and maintenance during angiogenesis. It contains an N-terminal IGF-binding protein-like motif and six von Willebrand-like cysteine-rich repeats (CRRs) in its extracellular domain. CRIM1 interacts with BMP4 and BMP7 via the CRRs and functions as an antagonist. CRIM1 is developmentally expressed in a number of tissues including the pancreas, kidney, placenta, brain and blood vessels. CRIM1 may participate in CNS and placental development by interacting with growth factors involved in motor neuron differentiation and survival.
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生物信息学
蛋白别名: CRIM-1; cysteine rich transmembrane BMP regulator 1 (chordin-like); Cysteine-rich motor neuron 1 protein; Cysteine-rich repeat-containing protein S52
基因别名: CRIM-1; CRIM1; S52; UNQ1886/PRO4330
UniProt ID: (Human) Q9NZV1
Entrez Gene ID: (Human) 51232
