Invitrogen

CSF3R Polyclonal Antibody

CSF3R Antibody in Immunocytochemistry (ICC/IF)

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CSF3R Antibody (PA5-28988) in ICC/IF

CSF3R Polyclonal Antibody detects CSF3R protein at cytoplasm by immunofluorescent analysis. Sample: THP-1 cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: CSF3R protein stained by CSF3R Polyclonal Antibody (Product # PA5-28988) diluted at 1:500. Blue: Hoechst 33342 staining.

CSF3R Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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产品信息

PA5-28988

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:3,000

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免疫组化 (IHC)

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免疫组化（石蜡） (IHC (P))

1:100-1:1,000

免疫细胞化学 (ICC/IF)

1:100-1:1,000

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产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fragment corresponding to a region within amino acids 164 and 432 of Human GCSF Receptor

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.36 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7, with 20% glycerol

内含物

0.025% ProClin 300

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2546464

产品详细信息

Recommended positive controls: THP-1, K562.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

CSF3R is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Four transcript variants encoding four different isoforms have been found for this gene, with three of the isoforms being membrane-bound and the other being secreted and soluble.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Roniciclib down-regulates stemness and inhibits cell growth by inducing nucleolar stress in neuroblastoma.

Scientific reports

Ognibene M,Pezzolo A

PA5-28988 was used in Western Blot, Immunohistochemistry, Immunocytochemistry to find that neurospheres derived from neuroblastoma stem-like cells showed a homogeneous staining for several key nucleolar proteins, such as Nucleolin, Nucleophosmin-1, Glypican-2 and PES-1.

Fri Jul 31 00:00:00 UTC 2020

Roniciclib down-regulates stemness and inhibits cell growth by inducing nucleolar stress in neuroblastoma.

Scientific reports

Ognibene M,Pezzolo A

Fri Jul 31 00:00:00 UTC 2020

Roniciclib down-regulates stemness and inhibits cell growth by inducing nucleolar stress in neuroblastoma.

Scientific reports

Ognibene M,Pezzolo A

Fri Jul 31 00:00:00 UTC 2020

Roniciclib down-regulates stemness and inhibits cell growth by inducing nucleolar stress in neuroblastoma.

Scientific reports

Ognibene M,Pezzolo A

Fri Jul 31 00:00:00 UTC 2020

Hypermethylation of CSF3R is a novel cisplatin resistance marker and predictor of response to postoperative chemotherapy in hepatoblastoma.

Hepatology research : the official journal of the Japan Society of Hepatology

Fujiyoshi S,Honda S,Minato M,Ara M,Suzuki H,Hiyama E,Taketomi A

PA5-28988 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to suggest that CSF3R hypermethylation was related to cisplatin resistance in HB patients and could be a predictor of postoperative chemotherapy, and indicate that CSF3R high methylation patients should be treated with non-CDDP regimens.

Fri May 01 00:00:00 UTC 2020

生物信息学

蛋白别名: CD114; CD114 antigen; colony stimulating factor 3 receptor (granulocyte); G-CSF receptor; G-CSF-R; Granulocyte colony-stimulating factor receptor

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基因别名: CD114; CSF3R; GCSFR; SCN7

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UniProt ID: (Human) Q99062

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Entrez Gene ID: (Human) 1441

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功能

receptor activity cytokine receptor activity protein binding transmembrane signal receptor

参与通路

defense response cell adhesion signal transduction cytokine-mediated signaling pathway neutrophil chemotaxis regulation of myeloid cell differentiation amelogenesis