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Immunogen sequence: EEDDKDAVGG GDLEDENELL VPTGKPGLGP GTGQPTSRWH AVPPQHTLGS VPGSSIALRP RPGEPGRDLA SSE
Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 82%.
Neuroglycan C is a transmembrane chondroitin sulfate proteoglycan that is exclusively expressed in the central nervous system. NGC gene expression is developmentally regulated being altered by addiction to psychostimulants and by nerve lesion. Its core protein has a particular multidomain structure differing from those of other known proteoglycans, and this protein is modified post-translationally in various ways such as phosphorylation and glycosylation. Neuroglycan C is a novel part-time proteoglycan that changes its structure from a proteoglycan form to a non-proteoglycan form without chondroitin sulfate chains during the development of the cerebellum and retina. Evidence suggests that Neuroglycan C is involved in neuronal circuit formation in the central nervous system.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Acidic leucine-rich EGF-like domain-containing brain protein; Chondroitin sulfate proteoglycan 5; chondroitin sulfate proteoglycan 5 (neuroglycan C); MGC44034; Neuroglycan C
基因别名: CALEB; CSPG5; NGC
UniProt ID: (Human) O95196
Entrez Gene ID: (Human) 10675