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Product Details
MA5-38251
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
GT1657
Immunogen
Recombinant protein encompassing a sequence within the center region of human CTH. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2898167
Product Specific Information
Centrifuge briefly prior to opening.
Target Information
This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this gene cause cystathioninuria. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CGL; cystathionase (cystathionine gamma-lyase); Cystathionine gamma-lyase; Cysteine desulfhydrase; Cysteine-protein sulfhydrase; Gamma-cystathionase; Homocysteine desulfhydrase; homoserine deaminase; homoserine dehydratase; MGC9471
Gene Aliases: 0610010I13Rik; AI314617; BC019483; CSE; CTH; Cys3
UniProt ID: (Human) P32929, (Mouse) Q8VCN5
Entrez Gene ID: (Human) 1491, (Mouse) 107869
cystathionine gamma-synthase activity
cystathionine gamma-lyase activity
protein binding
calmodulin binding
carbon-sulfur lyase activity
pyridoxal phosphate binding
L-cystine L-cysteine-lyase (deaminating)
homocysteine desulfhydrase activity
L-cysteine desulfhydrase activity
catalytic activity
cystathionine beta-lyase activity
lyase activity
lyase
sulfur amino acid catabolic process
cysteine metabolic process
protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
cysteine biosynthetic process via cystathionine
cysteine biosynthetic process
transsulfuration
endoplasmic reticulum unfolded protein response
positive regulation of I-kappaB kinase/NF-kappaB signaling
protein sulfhydration
positive regulation of NF-kappaB transcription factor activity
protein homotetramerization
hydrogen sulfide biosynthetic process
'de novo' L-methionine biosynthetic process
positive regulation of aortic smooth muscle cell differentiation
negative regulation of apoptotic signaling pathway
glutathione metabolic process
negative regulation of cell proliferation
cellular amino acid biosynthetic process
negative regulation of cell growth
negative regulation of apoptotic process
homocysteine metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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