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产品信息
PA5-120461
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human CTNNA3 (NP_001278062.1).
偶联物
形式
Liquid
浓度
1.58 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2914033
产品详细信息
Positive test controls include: LO2, 293T, Mouse spleen, Rat brain. The target is usually found in the following locations: Cytoplasm, cytoskeleton.
Immunogen sequence: MKSTQRREKQ GSMSAETPIT LNIDPQDLQV QTFTVEKLLE PLIIQVTTLV NCPQNPSSRK KGRSKRASVL LASVEEATWN LLDKGEKIAQ EATVLKDELT ASLEEVRKES EALKVSAERF TDDPCFLPKR EAVVQAARAL LAAVTRLLIL ADMIDVMCLL QHVSAFQRTF ESLKNVANKS DLQKTYQKLG KELENLDYLA FKRQQDLKSP NQRDEIAGAR ASLKENSPLL HSICSACLEH
靶标信息
Catenins are proteins that connect cadherin/beta-catenin cell adhesion complexes to the actin cytoskeleton. Although originally discovered in testis, alphaT-catenin is expressed in other tissues, the highest levels being observed in heart. Immunohistochemical analysis showed human alphaTcatenin localization at intercalated discs of cardiomyocytes and in peritubular myoid cells of testis. It is proven that alphaT-catenin can functionally restore cell-cell adhesion in colon cancer cells lacking alpha-catenins. This indicates that this protein is involved in the formation of specific cell-cell contacts in specific types of muscle cells. The encoded protein has about the same predicted size (100 kDa) as other alpha-catenins to which it shows an overall amino acid identity of 57%. In cells transfected with alphaT-catenin cDNA, interaction with alpha-catenin was demonstrated by coimmunoprecipitation. The 892_24D2S antibody against alphaT-catenin does not show any cross reaction with alphaE-catenin or alphaNcatenin in western blot analysis.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Alpha T-catenin; Alpha-3 catenin; alpha-catenin-like protein; alpha-T-catenin; Cadherin-associated protein; catenin (cadherin associated protein), alpha 3; catenin (cadherin-associated protein), alpha 3; catenin alpha 3; Catenin alpha-3; CTNNA3
基因别名: 4930429L08Rik; 4933408A16; ARVD13; Catna3; CTNNA3; RGD1559455; RGD1562230; VR22
UniProt ID: (Human) Q9UI47, (Mouse) Q65CL1
Entrez Gene ID: (Human) 29119, (Mouse) 216033, (Rat) 361839
