Invitrogen

CTPS Polyclonal Antibody

CTPS Antibody in Immunocytochemistry (ICC/IF)

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CTPS Antibody (PA5-65655) in ICC/IF

Immunofluorescent staining of CTPS in human cell line U-251 MG shows localization to plasma membrane, cytosol and actin filaments. Samples were probed using a CTPS Polyclonal Antibody (Product # PA5-65655).

CTPS Antibody in Immunohistochemistry (IHC)

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CTPS Antibody — Relative expression in different tissues in IHC: Detection of differential expression levels of CTPS demonstrates antibody specificity. Immunohistochemical analysis of CTPS using anti-CTPS Polyclonal Antibody (Product # PA5-65655), shows significant staining of CTPS in human smooth muscle and shows minimal or weak staining in human skeletal muscle tissues. The relative expression levels of CTPS within each tissue is shown using RNA-Seq. {RE}

产品信息

PA5-65655

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

1:500-1:1,000

免疫细胞化学 (ICC/IF)

0.25-2 µg/mL

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant Human CTPS. Recombinant protein control fragment (Product #RP-104921).

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.10 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2662624

产品详细信息

Immunogen sequence: PYFGLLLASVG RLSHYLQKGC RLSPRDTYSD RSGSSSPDSE ITELKFPSIN HD

Highest antigen sequence identity to the following orthologs - mouse 94%, rat 94%.

靶标信息

There are two genes encoding members of a new family of type II integral membrane proteins. Both are ubiquitously expressed, and tissue-specific alternative mRNA initiation and splicing generate at least two major isoforms of each protein, with the smaller isoforms being truncated at the N-terminus. These proteins are called nesprin-l and -2 for nuclear _envelope _spectrin repeat, as they are characterized by the presence of multiple, clustered spectrin repeats, bipartite nuclear localization sequences and a conserved C-terminal, single transmembrane domain. Transient transfection of EGFP-fusion expression constructs demonstrated their localization to the nuclear membrane with a novel C-terminal, TM-domain-containing sequence essential for perinuclear localization. Nesprin-l is developmentally regulated in both smooth and skeletal muscle and is relocalized from the nuclear envelope to the nucleus and cytoplasm during C2Cl2 myoblast differentiation. Nesprins may function as 'dystrophins of the nucleus' to maintain nuclear organization and structura integrity.

仅用于科研。不用于诊断过程。未经明确授权不得转售。