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CTRP1 Antibody (MA5-50947) in IHC (P)
Immunohistochemistry (Paraffin) analysis of CTRP1 in Human Kidney Tissue. Samples were incubated in CTRP1 monoclonal antibody (Product # MA5-50947) using a dilution of 30 µg/mL followed by HRP-Linked Caprine Anti-Mouse IgG at a dilution of 2 µg/mL and DAB staining.
产品信息
MA5-50947
产品规格
种属反应
Human,
Pig
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
C2
抗原
Recombinant Human C1QTNF1 protein, Arg26-Pro281 (Accession #Q9BXJ1)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.05% Proclin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_3090551
靶标信息
Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines. One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-alpha-related proteins (CTRPs) 1-7. Unlike adiponectin, which is expressed exclusively by differentiated adipocytes, the CTRPs are expressed in a wide variety of tissues. These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene. In obese (ob/ob) mice, RT-PCR analysis showed that mCTRP1 transcripts are seen at substantially higher levels in adipose tissues compared to those of normal mice.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C1q and tumor necrosis factor related protein 1; Complement C1q tumor necrosis factor-related protein 1; G protein coupled receptor interacting protein; G protein-coupled receptor-interacting protein; GIP
基因别名: C1QTNF1; CTRP1; GIP; UNQ310/PRO353; ZSIG37
UniProt ID: (Human) Q9BXJ1
Entrez Gene ID: (Pig) 100217377, (Human) 114897
positive regulation of cytosolic calcium ion concentration
negative regulation of platelet activation
positive regulation of gene expression
regulation of glucose metabolic process
positive regulation of MAPK cascade
protein homooligomerization
positive regulation of protein kinase B signaling
protein heterotrimerization
negative regulation of platelet aggregation
positive regulation of aldosterone secretion
