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产品信息
PA5-36277
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to amino acids 62-115 of human CUG-BP1/2
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2553450
产品详细信息
This antibody detects endogenous protein at a molecular weight of 50 and 54 kDa.
Purity is >95% by SDS-PAGE.
靶标信息
CUG-BP1 and CUG-BP2 are proteins that bind specifically to (CUG)8 oligonucleotides in vitro. While CUG-BP1 has the major binding activity in normal cells, nuclear CUG-BP2 binding activity increases in DM cells. Both CUG-BP1 and CUG-BP2 are isoforms of a novel heterogeneous nuclear ribonucleoprotein (hnRNP), hNab50. CUG-BP1, an RNA CUG triplet repeat binding protein, regulates splicing and translation of various RNAs. Expansion of RNA CUG repeats in the DMPK in DM is associated with alterations in binding activity of CUG-BP1 as well as alterations in the translation of the C/EBPb transcription factor. CUG-BP1 is an important regulator of initiation from different AUG codons of C/EBPb mRNA.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 50 kDa nuclear polyadenylated RNA-binding protein; Brain protein F41; bruno-like 2; Bruno-like protein 2; Bruno-like protein 3; CELF-1; CELF-2; CUG RNA-binding protein; CUG triplet repeat RNA-binding protein 1; CUG triplet repeat RNA-binding protein 2; CUG triplet repeat, RNA binding protein 1; CUG triplet repeat, RNA binding protein 2; CUG triplet repeat, RNA-binding protein 1; CUG-BP- and ETR-3-like factor 1; CUG-BP- and ETR-3-like factor 2; CUG-BP1; CUG-BP2; CUGBP Elav-like family member 1; CUGBP Elav-like family member 2; Cugbp- and Etr3-like factor 2; Deadenylation factor CUG-BP; Deadenylation factor EDEN-BP; EDEN-BP homolog; ELAV-type RNA-binding protein 3; embryo deadenylation element binding protein; Embryo deadenylation element-binding protein homolog; ETR-3; hNAPOR; mNapor; Neuroblastoma apoptosis-related RNA-binding protein; nuclear polyadenylated RNA-binding protein, 50-kD; RNA-binding protein BRUNOL-2; RNA-binding protein BRUNOL-3; RNA-binding protein Brunol3; rNapor
基因别名: 1600010O03Rik; AA407467; B230218O03; B230345P09Rik; BRUNOL2; BRUNOL3; C88023; CELF-2; CELF1; CELF2; CUG-BP; CUG-BP1; CUG-BP2; CUGBP; CUGBP1; CUGBP2; D230046B21Rik; D2Wsu101e; EDEN-BP; ETR-3; ETR3; HNAB50; mETR-3; NAB50; NAPOR; Napor-2
UniProt ID: (Human) Q92879, (Human) O95319, (Mouse) P28659, (Rat) Q4QQT3, (Rat) Q792H5, (Mouse) Q9Z0H4
Entrez Gene ID: (Human) 10658, (Human) 10659, (Mouse) 13046, (Rat) 362160, (Rat) 29428, (Mouse) 14007
