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CUG-BP2 Antibody (PA5-34856) in ICC/IF
CUG-BP2 Polyclonal Antibody detects CUGBP2 protein at nucleus by immunofluorescent analysis. Sample: U87-MG cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: CUGBP2 protein stained by CUG-BP2 Polyclonal Antibody (Product # PA5-34856) diluted at 1:500. Blue: Hoechst 33342 staining. Scale bar = 10 µm.
产品信息
PA5-34856
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein fragment contains a sequence corresponding to a region within amino acids 282 and 508 (O95319) of CUGBP2
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 1% BSA, 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2552208
产品详细信息
Recommended positive controls: PC-3, U87-MG, mouse brain.
Predicted reactivity: Mouse (90%), Rat (89%), Zebrafish (85%), Xenopus laevis (91%), Chicken (90%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
CUG-BP1 and CUG-BP2 are proteins that bind specifically to (CUG)8 oligonucleotides in vitro. While CUG-BP1 has the major binding activity in normal cells, nuclear CUG-BP2 binding activity increases in DM cells. Both CUG-BP1 and CUG-BP2 are isoforms of a novel heterogeneous nuclear ribonucleoprotein (hnRNP), hNab50. CUG-BP1, an RNA CUG triplet repeat binding protein, regulates splicing and translation of various RNAs. Expansion of RNA CUG repeats in the DMPK in DM is associated with alterations in binding activity of CUG-BP1 as well as alterations in the translation of the C/EBPb transcription factor. CUG-BP1 is an important regulator of initiation from different AUG codons of C/EBPb mRNA.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Bruno-like protein 3; CELF 2; CELF-2; CUG triplet repeat RNA-binding protein 2; CUG triplet repeat, RNA binding protein 2; CUG-BP- and ETR-3-like factor 2; CUG-BP2; CUGBP Elav-like family member 2; ELAV-type RNA-binding protein 3; ETR-3; hNAPOR; mNapor; neur; Neuroblastoma apoptosis-related RNA-binding protein; RNA-binding protein BRUNOL-3; RP23-124P7.1
基因别名: B230218O03; B230345P09Rik; BRUNOL3; C88023; CELF-2; CELF2; CUG-BP2; CUGBP2; D230046B21Rik; ETR-3; ETR3; mETR-3; NAPOR; Napor-2
UniProt ID: (Human) O95319, (Mouse) Q9Z0H4
Entrez Gene ID: (Human) 10659, (Mouse) 14007
