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CXCL6 Antibody (PA5-115276) in ICC/IF
Immunocytochemistry analysis of CXCL6 in HeLa cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-115276) at a dilution of 1:200 (1 hr at 37°C). Secondary staining was applied with mouse anti-beta tubulin; AlexaFluor 594 conjugated goat anti-rabbit IgG (Red); AlexaFluor 88 conjugated goat anti-mouse IgG (Green) and DAPI (blue) using a dilution of 1:200 (1 hr at 37°C).
产品信息
PA5-115276
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human CXCL6(Accession P80162), corresponding to amino acid residues R10-P60.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2899912
产品详细信息
Antibody detects endogenous levels of total GCP2.
靶标信息
CXCL6 is a chemotactic for neutrophil granulocytes. It signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram-negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C Cmotif chemokine; C X C motif chemokine; C-X-C motif chemokine 5; C-X-C motif chemokine 6; CC motif chemokine; CCmotif chemokine; chemokine (C-X-C motif) ligand 5; chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2); Chemokine alpha 3; CKA-3; CKA3; CXC; CXC chemokine LIX; CXC motif chemokine; CXCL; Cytokine LIX; GCP-2; Granulocyte chemotactic protein 2; small inducible cytokine subfamily B (Cys-X-Cys), member 6 (granulocyte chemotactic protein 2); Small inducible cytokine subfamily B (Cys-X-Cys), member b; Small-inducible cytokine B5; Small-inducible cytokine B6
基因别名: CKA-3; Cxcl5; CXCL6; GCP-2; GCP2; Scyb5; SCYB6
UniProt ID: (Human) P80162, (Rat) P97885
Entrez Gene ID: (Human) 6372, (Rat) 60665
neutrophil mediated immunity
positive regulation of leukocyte chemotaxis
chemotaxis
inflammatory response
immune response
signal transduction
G-protein coupled receptor signaling pathway
cell-cell signaling
response to lipopolysaccharide
regulation of cell proliferation
defense response to bacterium
cell chemotaxis
chemokine-mediated signaling pathway
leukocyte homeostasis
cytokine production
response to gamma radiation
positive regulation of neuron projection development
midbrain development
organ regeneration
regulation of chemokine production
positive regulation of JAK-STAT cascade
regulation of neutrophil mediated killing of gram-negative bacterium
cellular response to lipopolysaccharide
