Invitrogen

CXCL9 Polyclonal Antibody

CXCL9 Antibody in Immunocytochemistry (ICC/IF)

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CXCL9 Antibody (PA5-34743) in ICC/IF

CXCL9 Polyclonal Antibody detects MIG protein at cytoplasm by immunofluorescent analysis. Sample: A431 cells were fixed in 4% paraformaldehyde at RT for 5 min. Green: MIG protein stained by CXCL9 Polyclonal Antibody (Product # PA5-34743) diluted at 1:1,000. Blue: Hoechst 33342 staining.

CXCL9 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CXCL9 Antibody in Immunohistochemistry (IHC)

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产品信息

PA5-34743

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:3,000

免疫组化 (IHC)

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免疫组化（石蜡） (IHC (P))

1:100-1:1,000

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免疫细胞化学 (ICC/IF)

1:100-1:1,000

产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide contains a sequence corresponding to a region within amino acids 61 and 75 of MIG

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.33 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7, with 20% glycerol

内含物

0.025% ProClin 300

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2552095

产品详细信息

Recommended positive controls: A431.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

MIG, also known as CXCL9, is a T-cell chemoattractant inducible by gamma interferon that is a member of the CXC chemokine family of cytokines.This gene is mapped to 4q21. It is noted that, although the best-described activities of the chemokines are as chemotactic factors, chemokines also have an effect on T-cell activation, angiogenesis, and HIV infection. While most CXC chemokines are chemotactic for neutrophils, MIG and INP10 are unusual and similar in being CXC chemokines that are chemotactic for lymphocytes and inactive in neutrophils.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

CXCL9 inhibits tumour growth and drives anti-PD-L1 therapy in ovarian cancer.

British journal of cancer

Seitz S,Dreyer TF,Stange C,Steiger K,Bräuer R,Scheutz L,Multhoff G,Weichert W,Kiechle M,Magdolen V,Bronger H

PA5-34743 was used in Immunohistochemistry to conclude that CXCL9 is a driver of successful ICB in preclinical ovarian cancer. Besides being a feasible predictive biomarker, CXCL9-inducing agents thus represent attractive combination partners to improve ICB in this cancer entity.

Wed Jun 01 00:00:00 UTC 2022

CXCL9 inhibits tumour growth and drives anti-PD-L1 therapy in ovarian cancer.

British journal of cancer

Seitz S,Dreyer TF,Stange C,Steiger K,Bräuer R,Scheutz L,Multhoff G,Weichert W,Kiechle M,Magdolen V,Bronger H

Wed Jun 01 00:00:00 UTC 2022

KCNK3 Mutation Causes Altered Immune Function in Pulmonary Arterial Hypertension Patients and Mouse Models.

International journal of molecular sciences

West JD,Austin ED,Rizzi EM,Yan L,Tanjore H,Crabtree AL,Moore CS,Muthian G,Carrier EJ,Jacobson DA,Hamid R,Kendall PL,Majka S,Rathinasabapathy A

PA5-34743 was used in Immunohistochemistry (Paraffin) to suggest that altered circulating immune cells may drive PAH susceptibility in patients with KCNK3 mutation.

Sun May 09 00:00:00 UTC 2021

KCNK3 Mutation Causes Altered Immune Function in Pulmonary Arterial Hypertension Patients and Mouse Models.

International journal of molecular sciences

West JD,Austin ED,Rizzi EM,Yan L,Tanjore H,Crabtree AL,Moore CS,Muthian G,Carrier EJ,Jacobson DA,Hamid R,Kendall PL,Majka S,Rathinasabapathy A

PA5-34743 was used in Immunohistochemistry (Paraffin) to suggest that altered circulating immune cells may drive PAH susceptibility in patients with KCNK3 mutation.

Sun May 09 00:00:00 UTC 2021

生物信息学

蛋白别名: C Cmotif chemokine; C X C motif chemokine; C-X-C motif chemokine 9; CC motif chemokine; CCmotif chemokine; chemokine (C-X-C motif) ligand 9; CXC; CXC motif chemokine; CXCL; Gamma-interferon-induced monokine; HuMIG; monokine induced by gamma interferon; Monokine induced by interferon-gamma; Small-inducible cytokine B9

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基因别名: CMK; crg-10; CXCL9; Humig; MIG; SCYB9

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UniProt ID: (Human) Q07325

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Entrez Gene ID: (Human) 4283

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功能

cytokine activity protein binding chemokine activity CXCR3 chemokine receptor binding chemokine

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