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产品信息
CXCR20-FITC
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide:EDLSNYSYSSTLPPFLLDAAPCCorresponding to amino acids 18-39 of Human CXCR2.
偶联物
激发/发射光谱
498/517 nm
查看光谱
形式
Liquid
浓度
0.5-1.5 mg/mL
纯化类型
Affinity chromatography
保存液
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, store in dark
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
CXCR2 is a receptor for interleukin-8, which is a powerful neutrophil chemotactic factor. It is a member of the GPCR family. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to GRO/MGSA and NAP-2 also with a high affinity. It has been reported to be expressed in a wide variety of tissues. ESTs have been isolated from human placenta and thymus libraries.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
How to use the Panel Builder
Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.
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生物信息学
蛋白别名: C Cmotif chemokine; C X C motif chemokine; C-X-C chemokine receptor type 2; CC motif chemokine; CCmotif chemokine; CD182; CD182 antigen; CDw128b; chemokine (C-X-C motif) receptor 2; chemokine (C-X-C) receptor 2; chemokine (CXC) receptor 2; CXC; CXC motif chemokine; CXC-R2; CXCR-2; CXCR2 gene for IL8 receptor type B; GRO/MGSA receptor; High affinity interleukin-8 receptor B; IL-8 receptor alpha chain; Il-8 receptor b; IL-8 receptor beta; IL-8 receptor type 2; IL-8R B; interleukin 8 receptor B; interleukin 8 receptor type 2; interleukin 8 receptor, beta; interleukin-8 receptor type B
基因别名: CD128; CD182; CDw128; CDw128b; CMKAR2; CXCR2; Gpcr16; IL-8rb; IL-8Rh; IL8R2; IL8RA; IL8RB; mIL-8RH
UniProt ID: (Human) P25025, (Mouse) P35343, (Rat) P35407
Entrez Gene ID: (Human) 3579, (Mouse) 12765, (Rat) 29385
acute inflammatory response to antigenic stimulus
positive regulation of leukocyte chemotaxis
chemotaxis
cellular defense response
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
positive regulation of cell proliferation
positive regulation of cardiac muscle cell apoptotic process
neutrophil chemotaxis
receptor internalization
negative regulation of neutrophil apoptotic process
interleukin-8-mediated signaling pathway
neutrophil activation
negative regulation of apoptotic process
positive regulation of vascular permeability
positive regulation of angiogenesis
chemokine-mediated signaling pathway
metanephric tubule morphogenesis
positive regulation of neutrophil chemotaxis
dendritic cell chemotaxis
inflammatory response
midbrain development
