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CXXC4 Antibody (PA5-26391) in IHC (P)
Immunohistochemistry analysis of CXXC4 in formalin-fixed and paraffin-embedded human colon carcinoma. Samples were incubated with CXXC4 polyclonal antibody (Product # PA5-26391) which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
产品信息
PA5-26391
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 158-185 amino acids from the C-terminal region of human CXXC4
偶联物
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Protein A, Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2543891
产品详细信息
This antibody is predicted to react with rat based on sequence homology.
靶标信息
CXXC4 is zinc finger protein that binds directly to the PDZ domain of DVL1, a protein involved in the Wnt signaling pathway, through its C-terminal region. CXXC4 interaction with DVL1 competes with DVL1-AXIN binding, although the affinity of DVL1 for CXXC4 is lower than that for AXIN. In mouse fibroblasts, CXXC4 suppressed Wnt3a induction of beta-catenin and inhibited Wnt3a-dependent TCF4 activation, suggesting that CXXC4 acts as a negative regulator of the Wnt signaling pathway and functions between DVL and beta-catenin. Recent reports suggest that decreased CXXC4 expression is associated with kidney cancer metastasis, cell proliferation, reduced apoptosis in response to cancer drugs, and upregulation of genes involved with proliferation, invasion and cell survival, suggesting that CXXC4 plays a critical role in tumor progression in kidney cancer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CXXC finger 4; CXXC-type zinc finger protein 4; Dvl-binding protein IDAX (inhibition of the Dvl and Axin complex); inhibition of the Dvl and axin complex protein
基因别名: 9330210J02Rik; C030003J12Rik; IDAX
Entrez Gene ID: (Human) 80319, (Mouse) 319478
