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Product Details
PA5-61902
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CYP11B2. Recombinant protein control fragment (Product #RP-99283).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2640315
Product Specific Information
Immunogen sequence: FLYSLGRNAA LFPRPERYNP QRWLDIRGSG RNFHHVPFGF GMRQCL
Highest antigen sequence identity to the following orthologs: Mouse - 65%, Rat - 65%.
Target Information
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and is involved in the conversion of progesterone to cortisol in the adrenal cortex. Mutations in this gene cause congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency. Transcript variants encoding different isoforms have been noted for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ALDOS; Aldosterone synthase; Aldosterone-synthesizing enzyme; Corticosterone 18-monooxygenase, CYP11B2; CYPXIB2; Cytochrome P-450Aldo; Cytochrome P-450C18; Cytochrome P450 11B2, mitochondrial; cytochrome P450, family 11, subfamily B, polypeptide 2; cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 2; mitochondrial cytochrome P450, family 11, subfamily B, polypeptide 2; P-450C 18; P450C 18; Steroid 11-beta-hydroxylase, CYP11B2; steroid 11-beta-monooxygenase; steroid 11-beta/18-hydroxylase; Steroid 18-hydroxylase; steroid 18-hydroxylase, aldosterone synthase, P450C18, P450aldo
Gene Aliases: ALDOS; CPN2; CYP11B; CYP11B2; CYP11BL; CYPXIB2; P-450C18; P450aldo; P450C18
UniProt ID: (Human) P19099
Entrez Gene ID: (Human) 1585
steroid 11-beta-monooxygenase activity
iron ion binding
steroid hydroxylase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
heme binding
corticosterone 18-monooxygenase activity
regulation of blood volume by renal aldosterone
renal water homeostasis
C21-steroid hormone biosynthetic process
mineralocorticoid biosynthetic process
cholesterol metabolic process
sterol metabolic process
aldosterone biosynthetic process
cellular response to hormone stimulus
cortisol biosynthetic process
cellular response to potassium ion
secondary metabolite biosynthetic process
potassium ion homeostasis
sodium ion homeostasis
oxidation-reduction process
cellular response to peptide hormone stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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