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产品信息
PA5-69790
产品规格
种属反应
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
synthetic peptide directed towards the C-terminal region of rat CYP1B1
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2691354
产品详细信息
This target displays homology in the following species: Cow: 100%; Dog: 93%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
靶标信息
CYP1B1 is a 543 amino acid intracellular protein localized to the endoplasmic reticulum. It belongs to the cytochrome P450 super family of enzymes which are monooxygenases and it catalyzes many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol and is also involved in the metabolism of substances active in the eye growth and differentiation and hence plays a putative role in ocular development. Mutated proteins are known to cause primary congenital glaucoma.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CYPIB1; Cytochrome P450 1B1; cytochrome P450, subfamily 1B, polypeptide 1; Cytochrome P450RAP; Hydroperoxy icosatetraenoate dehydratase; P450RAP
基因别名: Cyp1b1
UniProt ID: (Rat) Q64678
Entrez Gene ID: (Rat) 25426
monooxygenase activity
iron ion binding
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
heme binding
aromatase activity
oxidoreductase
oxygenase
metabolite interconversion enzyme
angiogenesis
trabecular meshwork development
DNA modification
cellular aromatic compound metabolic process
xenobiotic metabolic process
nitric oxide biosynthetic process
cell adhesion
response to nutrient
steroid metabolic process
estrogen metabolic process
negative regulation of cell proliferation
male gonad development
intrinsic apoptotic signaling pathway in response to oxidative stress
toxin metabolic process
response to toxic substance
response to organic substance
positive regulation of vascular endothelial growth factor production
response to organic cyclic compound
positive regulation of smooth muscle cell migration
dibenzo-p-dioxin metabolic process
arachidonic acid metabolic process
collagen fibril organization
adrenal gland development
negative regulation of cell migration
negative regulation of NF-kappaB transcription factor activity
response to follicle-stimulating hormone
response to estradiol
negative regulation of cell adhesion mediated by integrin
benzene-containing compound metabolic process
retinol metabolic process
retinal metabolic process
positive regulation of apoptotic process
endothelial cell migration
estrous cycle
positive regulation of translation
positive regulation of angiogenesis
positive regulation of JAK-STAT cascade
membrane lipid catabolic process
response to arsenic-containing substance
blood vessel morphogenesis
response to steroid hormone
oxidation-reduction process
retina vasculature development in camera-type eye
retinal blood vessel morphogenesis
ganglion development
cellular response to hydrogen peroxide
cellular response to cAMP
cellular response to tumor necrosis factor
cellular response to luteinizing hormone stimulus
cellular response to cortisol stimulus
cellular response to progesterone stimulus
cellular response to organic cyclic compound
response to dexamethasone
endothelial cell-cell adhesion
response to indole-3-methanol
regulation of reactive oxygen species metabolic process
positive regulation of reactive oxygen species metabolic process
positive regulation of DNA biosynthetic process
