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产品信息
PA5-99833
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human CYP2A6(Accession P11509), corresponding to amino acid residues S4-M54.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2818766
产品详细信息
Antibody detects endogenous levels of total Cytochrome P450 2A6/7/13.
靶标信息
The cytochrome P450 (P450) superfamily of enzymes is one of three enzyme systems which metabolize the fatty acid arachadonic acid (AA) to regulators of vascular tone. P450 enzymes are monooxygenase enzymes which require several co-factors such as nicotinamide adenine dinucleotide phosphate (NADPH) and P450 reductase. There are over 200 known genes which encode P450s. Epoxygenases are those P450s which metabolize AA to epoxyeicosatrienoic acid (EETs) and omega-hydroxylases are those P450s which produce 19- and 20-hydroxyeicosatetraenoic acids (19- and 20-HETE). As well as fatty acid metabolism, P450s also metabolize many drugs and toxins. Cytochrome P450 3A4 is abundantly expressed in liver and small intestine and is inducible by barbiturates, glucocorticoids and rifampicin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 1,4-cineole 2-exo-monooxygenase; Coumarin 7-hydroxylase; CYPIIA13; CYPIIA6; CYPIIA7; Cytochrome P450 2A13; Cytochrome P450 2A6; Cytochrome P450 2A7; Cytochrome P450 IIA3; Cytochrome P450 IIA4; Cytochrome P450(I); cytochrome P450, family 2, subfamily A, polypeptide 13; cytochrome P450, family 2, subfamily A, polypeptide 6; cytochrome P450, family 2, subfamily A, polypeptide 7; cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 13; cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 6; cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 7; cytochrome P450IIA4; flavoprotein-linked monooxygenase; xenobiotic monooxygenase
基因别名: CPA6; CPA7; CPAD; CYP2A; CYP2A13; CYP2A3; CYP2A6; CYP2A7; CYPIIA13; CYPIIA6; CYPIIA7; P450-IIA4; P450C2A; P450PB
UniProt ID: (Human) Q16696, (Human) P11509, (Human) P20853
Entrez Gene ID: (Human) 1553, (Human) 1548, (Human) 1549
iron ion binding
coumarin 7-hydroxylase activity
arachidonic acid epoxygenase activity
steroid hydroxylase activity
oxygen binding
heme binding
aromatase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
enzyme binding
oxidoreductase
oxygenase
metabolite interconversion enzyme
