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CYP2C19 Antibody (PA5-114368) in IHC (P)
Immunohistochemistry analysis of CYP2C19 in paraffin-embedded human liver cancer tissues. Antigen retrieval was performed with citrate buffer (pH6, 20 min). Samples were blocked with 10% goat serum and incubated in CYP2C19 polyclonal antibody (Product # PA5-114368) at a dilution of 1 µg/mL (overnight, 4°C), followed by biotinylated goat anti-rabbit IgG (30 min, 37°C) and Strepavidin-Biotin-Complex (SABC) wi... View More
产品信息
PA5-114368
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence of human Cytochrome p450 2C19/CYP2C19 (QNQQSEFTIENLVITAADLLGAGTETT).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Affinity chromatography
保存液
PBS with 4mg trehalose
内含物
0.05mg sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2884824
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
靶标信息
CYP2C19 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within its gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC17; CYPIIC19; cyto; cytochrome P-450 II C; Cytochrome P450 2C19; cytochrome P450, family 2, subfamily C, polypeptide 19; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 19; Cytochrome P450-11A; Cytochrome P450-254C; Fenbendazole monooxygenase (4'-hydroxylating); flavoprotein-linked monooxygenase; mephenytoin 4'-hydroxylase; Mephenytoin 4-hydroxylase; microsomal monooxygenase; P450-11A; P450-254C; S-mephenytoin 4-hydroxylase; xenobiotic monooxygenase
基因别名: CPCJ; CYP2C; CYP2C19; CYPIIC17; CYPIIC19; P450C2C; P450IIC19
UniProt ID: (Human) P33261
Entrez Gene ID: (Human) 1557
monooxygenase activity
iron ion binding
arachidonic acid epoxygenase activity
steroid hydroxylase activity
oxidoreductase activity
(S)-limonene 6-monooxygenase activity
(S)-limonene 7-monooxygenase activity
oxygen binding
enzyme binding
heme binding
(R)-limonene 6-monooxygenase activity
oxidoreductase
oxygenase
metabolite interconversion enzyme
